Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system.

Sato, Yuki; Joumura, Tatsuru; Nashimoto, Shunsuke; Yokoyama, Sayaka; Takekuma, Yoh; Yoshida, Hideto; Sugawara, Mitsuru

doi:10.1016/j.ejpb.2018.02.013


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Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/78797

Title:	Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system.
Authors:	Sato, Yuki Browse this author →KAKEN DB
	Joumura, Tatsuru Browse this author
	Nashimoto, Shunsuke Browse this author
	Yokoyama, Sayaka Browse this author
	Takekuma, Yoh Browse this author →KAKEN DB
	Yoshida, Hideto Browse this author
	Sugawara, Mitsuru Browse this author →KAKEN DB
Keywords:	lutein (PubChem CID: 5281243)
	lymph
	absorption
	solid dispersion
	self-microemulsifying drug delivery system
	intestine
Issue Date:	Jun-2018
Journal Title:	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Volume:	127
Start Page:	171
End Page:	176
Publisher DOI:	10.1016/j.ejpb.2018.02.013
PMID:	29428792
Abstract:	Lutein is located in the macula lutea in the human eye. Since humans cannot synthesize lutein de novo, it must be digested as food. Some studies including our previous study showed very low absorption of lutein after oral administration. These studies also suggested that the absorption route of lutein from the small intestine involves not only the blood but also the lymph. The aim of this study was to clarify the transfer of lutein into lymph and the tissue distribution after oral administration of a solid dispersion (SD) and a self-microemulsifying drug delivery system (SMEDDS) for improvement of the absorption. We used thoracic lymph-cannulated rats. It was shown that the plasma concentrations of lutein in the SD and SMEDDS groups were increased compared with that in the powder group. The absorption of lutein after oral administration of each formulation was clearly evaluated by its cumulative amount in lymph. Our data clearly showed that lutein is transferred into the lymph stream from the small intestine.
Rights:	©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Rights:	http://creativecommons.org/licenses/by-nc-nd/4.0/
Type:	article (author version)
URI:	http://hdl.handle.net/2115/78797
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤夕紀

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