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Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood : The Hokkaido study

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Title: Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood : The Hokkaido study
Other Titles: Maternal dioxins and cord blood hormones
Authors: Miyashita, Chihiro Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Mitsui, Takahiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Hori, Tsuguhide Browse this author
Cho, Kazutoshi Browse this author →KAKEN DB
Moriya, Kimihiko Browse this author →KAKEN DB
Shinohara, Nobuo Browse this author →KAKEN DB
Nonomura, Katsuya Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Dioxin-like compounds
Reproductive hormones
Cord blood
Prenatal exposure
Issue Date: Aug-2018
Publisher: Elsevier
Journal Title: Environment international
Volume: 117
Start Page: 175
End Page: 185
Publisher DOI: 10.1016/j.envint.2018.04.046
Abstract: Background: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. Objective: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. Methods: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples. Results: Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples. Conclusions: Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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