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Effect of microtubule immobilization by glutaraldehyde on kinesin-driven cargo transport

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Title: Effect of microtubule immobilization by glutaraldehyde on kinesin-driven cargo transport
Authors: Nasrin, Syeda Rubaiya Browse this author
Kabir, Arif Md. Rashedul Browse this author
Sada, Kazuki Browse this author
Kakugo, Akira Browse this author →KAKEN DB
Issue Date: 4-Feb-2020
Publisher: Nature Publishing Group
Journal Title: Polymer journal
Publisher DOI: 10.1038/s41428-020-0309-x
Abstract: The glutaraldehyde fixation method for fixing tissues is attractive for its ease of use and straightforward surface chemistry. We investigated the effect of glutaraldehyde-induced microtubule immobilization on kinesin-driven cargo transport along microtubules and found that at low glutaraldehyde concentrations, the microtubule-kinesin interaction remains unperturbed. Such findings may facilitate the application of the glutaraldehyde fixation method for many in vitro studies aiming to build nanodevices powered by the microtubule-motor protein interaction.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 角五 彰

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