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Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography

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Title: Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography
Authors: Horie, Tatsunori Browse this author
Nishida, Mutsumi Browse this author →KAKEN DB
Tanimura, Shun Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Tamai, Erika Browse this author
Morimura, Yutaka Browse this author
Nishibata, Yuka Browse this author
Masuda, Sakiko Browse this author →KAKEN DB
Nakazawa, Daigo Browse this author →KAKEN DB
Tomaru, Utano Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Ishizu, Akihiro Browse this author →KAKEN DB
Keywords: Animal model
Power Doppler
Rheumatoid arthritis
Superb microvascular imaging
Synovitis
Ultrasound
Issue Date: Aug-2019
Publisher: Elsevier
Journal Title: Ultrasound in medicine & biology
Volume: 45
Issue: 8
Start Page: 2086
End Page: 2093
Publisher DOI: 10.1016/j.ultrasmedbio.2019.04.002
PMID: 31085028
Abstract: This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue before overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahigh-frequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r = 0.585, p = 0.022) but not with the total number of vessels. US with SMI using ultrahigh-frequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats.
Rights: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/79159
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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