| Title: | Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography |
| Authors: | Horie, Tatsunori Browse this author |
| Nishida, Mutsumi Browse this author →KAKEN DB |
| Tanimura, Shun Browse this author |
| Kamishima, Tamotsu Browse this author →KAKEN DB |
| Tamai, Erika Browse this author |
| Morimura, Yutaka Browse this author |
| Nishibata, Yuka Browse this author |
| Masuda, Sakiko Browse this author →KAKEN DB |
| Nakazawa, Daigo Browse this author →KAKEN DB |
| Tomaru, Utano Browse this author →KAKEN DB |
| Atsumi, Tatsuya Browse this author →KAKEN DB |
| Ishizu, Akihiro Browse this author →KAKEN DB |
| Keywords: | Animal model |
| Power Doppler |
| Rheumatoid arthritis |
| Superb microvascular imaging |
| Synovitis |
| Ultrasound |
| Issue Date: | Aug-2019 |
| Publisher: | Elsevier |
| Journal Title: | Ultrasound in medicine & biology |
| Volume: | 45 |
| Issue: | 8 |
| Start Page: | 2086 |
| End Page: | 2093 |
| Publisher DOI: | 10.1016/j.ultrasmedbio.2019.04.002 |
| PMID: | 31085028 |
| Abstract: | This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue before overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahigh-frequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r = 0.585, p = 0.022) but not with the total number of vessels. US with SMI using ultrahigh-frequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79159 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
