HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >

Boron-Catalyzed alpha-Amination of Carboxylic Acids

Files in This Item:
Morisawa_OL_revise_final.pdf385.68 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Boron-Catalyzed alpha-Amination of Carboxylic Acids
Authors: Morisawa, Takuto Browse this author
Sawamura, Masaya Browse this author →KAKEN DB
Shimizu, Yohei Browse this author →KAKEN DB
Issue Date: 20-Sep-2019
Publisher: American Chemical Society
Journal Title: Organic letters
Volume: 21
Issue: 18
Start Page: 7466
End Page: 7469
Publisher DOI: 10.1021/acs.orglett.9b02769
Abstract: A boron-catalyzed alpha-amination of simple carboxylic acids was developed. Catalytically generated boron enolates of carboxylic acids reacted with an electrophilic aminating reagent, diisopropylazodicarboxylate, to provide amino acid derivatives. The catalysis afforded not only alpha-monosubstituted glycine derivatives but also alpha,alpha-disubstituted derivatives. The resulting alpha-aminocarboxylic acid was easily converted to carboxylic acid derivatives. Extension to a catalytic asymmetric variant was possible by introducing a chiral ligand on the boron catalyst.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 澤村 正也

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University