HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >

Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water

Files in This Item:
1.5115519.pdf1.11 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79314

Title: Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water
Authors: Matsuya, Yusuke Browse this author →KAKEN DB
Kai, Takeshi Browse this author →KAKEN DB
Yoshii, Yuji Browse this author
Yachi, Yoshie Browse this author
Naijo, Shingo Browse this author
Date, Hiroyuki Browse this author →KAKEN DB
Sato, Tatsuhiko Browse this author →KAKEN DB
Issue Date: 28-Sep-2019
Publisher: American Institute of Physics (AIP)
Journal Title: Journal of Applied Physics
Volume: 126
Issue: 12
Start Page: 124701
Publisher DOI: 10.1063/1.5115519
Abstract: DNA strand breaks are induced in cells mainly composed of liquid water along ionizing radiation tracks. For estimating DNA strand break yields, track structures for electrons in liquid water in Monte Carlo simulations are of great importance; however, detailed simulations to obtain both energy deposition and free radical reaction to DNA are time-consuming processes. Here, we present a simple model for estimating yields of single- and double-strand breaks (SSB, DSB, and DSB/SSB ratio) based only on spatial patterns of inelastic interactions (i.e., ionization and electronic excitation) generated by electrons, which are evaluated by the track structure mode of Particle and Heavy Ion Transport code System without analyzing the production and diffusion of free radicals. In the present model, the number of events per track and that of a pair composed of two events within 3.4 nm (10 base pairs) were stochastically sampled for calculating SSB and DSB yields. The results calculated by this model agree well with other simulations and experimental data on the DSB yield and the DSB/SSB ratio for monoenergetic electron irradiation. This model also demonstrates the relative biological effectiveness at the DSB endpoint for various photon irradiations, indicating that the spatial pattern composed of ionization and electronic excitation without physicochemical and chemical stages is sufficient to obtain the impact of electrons on the initial DNA strand break induction.
Rights: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Matsuya, Yusuke, et al. "Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water." Journal of Applied Physics 126.12 (2019): 124701 and may be found at https://doi.org/10.1063/1.5115519
Type: article
URI: http://hdl.handle.net/2115/79314
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松谷 悠佑

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University