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Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water
| Title: | Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water |
| Authors: | Matsuya, Yusuke Browse this author →KAKEN DB | | Kai, Takeshi Browse this author →KAKEN DB | | Yoshii, Yuji Browse this author | | Yachi, Yoshie Browse this author | | Naijo, Shingo Browse this author | | Date, Hiroyuki Browse this author →KAKEN DB | | Sato, Tatsuhiko Browse this author →KAKEN DB |
| Issue Date: | 28-Sep-2019 |
| Publisher: | American Institute of Physics (AIP) |
| Journal Title: | Journal of Applied Physics |
| Volume: | 126 |
| Issue: | 12 |
| Start Page: | 124701 |
| Publisher DOI: | 10.1063/1.5115519 |
| Abstract: | DNA strand breaks are induced in cells mainly composed of liquid water along ionizing radiation tracks. For estimating DNA strand break yields, track structures for electrons in liquid water in Monte Carlo simulations are of great importance; however, detailed simulations to obtain both energy deposition and free radical reaction to DNA are time-consuming processes. Here, we present a simple model for estimating yields of single- and double-strand breaks (SSB, DSB, and DSB/SSB ratio) based only on spatial patterns of inelastic interactions (i.e., ionization and electronic excitation) generated by electrons, which are evaluated by the track structure mode of Particle and Heavy Ion Transport code System without analyzing the production and diffusion of free radicals. In the present model, the number of events per track and that of a pair composed of two events within 3.4 nm (10 base pairs) were stochastically sampled for calculating SSB and DSB yields. The results calculated by this model agree well with other simulations and experimental data on the DSB yield and the DSB/SSB ratio for monoenergetic electron irradiation. This model also demonstrates the relative biological effectiveness at the DSB endpoint for various photon irradiations, indicating that the spatial pattern composed of ionization and electronic excitation without physicochemical and chemical stages is sufficient to obtain the impact of electrons on the initial DNA strand break induction. |
| Rights: | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Matsuya, Yusuke, et al. "Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water." Journal of Applied Physics 126.12 (2019): 124701 and may be found at https://doi.org/10.1063/1.5115519 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79314 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松谷 悠佑
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