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Catalytic Enantioselective Methylene C(sp(3))-H Amidation of 8-Alkylquinolines Using a Cp*Rh-III/Chiral Carboxylic Acid System
| Title: | Catalytic Enantioselective Methylene C(sp(3))-H Amidation of 8-Alkylquinolines Using a Cp*Rh-III/Chiral Carboxylic Acid System |
| Authors: | Fukagawa, Seiya Browse this author | | Kojima, Masahiro Browse this author | | Yoshino, Tatsuhiko Browse this author →KAKEN DB | | Matsunaga, Shigeki Browse this author →KAKEN DB |
| Keywords: | asymmetric catalysis | | C-H activation | | chiral carboxylic acid | | quinoline | | rhodium |
| Issue Date: | 8-Oct-2019 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Angewandte chemie-international edition |
| Volume: | 58 |
| Issue: | 50 |
| Start Page: | 18154 |
| End Page: | 18158 |
| Publisher DOI: | 10.1002/anie.201911268 |
| Abstract: | Catalytic enantioselective directed methylene C(sp(3))-H amidation reactions of 8-alkylquinolines using a Cp*Rh-III/chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl-based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C-H bonds, which leads to the formation of C-N bonds with good enantioselectivity. |
| Rights: | This is the peer reviewed version of the following article: Seiya Fukagawa et al. Catalytic Enantioselective Methylene C(sp3)−H Amidation of 8‐Alkylquinolines Using a Cp*RhIII/Chiral Carboxylic Acid System. Angewandte chemie-international edition, 2019, 58(50), 18154-18158, which has been published in final form at https://doi.org/10.1002/anie.201911268. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79493 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉野 達彦
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