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Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp(3))-H Activation of Thioamides
| Title: | Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp(3))-H Activation of Thioamides |
| Authors: | Sekine, Daichi Browse this author | | Ikeda, Kazuki Browse this author | | Fukagawa, Seiya Browse this author | | Kojima, Masahiro Browse this author | | Yoshino, Tatsuhiko Browse this author | | Matsunaga, Shigeki Browse this author |
| Issue Date: | 28-Oct-2019 |
| Publisher: | American Chemical Society |
| Journal Title: | Organometallics |
| Volume: | 38 |
| Issue: | 20 |
| Start Page: | 3921 |
| End Page: | 3926 |
| Publisher DOI: | 10.1021/acs.organomet.9b00407 |
| Abstract: | Enantioselective C-H functionalization reactions using trivalent group 9 metals (Co, Rh, Ir) have been investigated mainly on the basis of the development of well-designed chiral cyclopentadienyl (Cp) ligands. Although it has recently been demonstrated that chiral carboxylic acids combined with achiral Cp-type ligands can enable highly enantioselective C-H functionalization reactions, the structural diversity of the applied chiral acids remains limited. Here, we report that chiral 2-aryl ferrocene carboxylic acids, which are easily obtained from diastereoselective ortho lithiation and Suzuki-Miyaura coupling, can serve as external chiral sources for the Cp*Co-III-catalyzed enantioselective C(sp(3))-H amidation of alpha-aryl thioamides using dioxazolones. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organometallics, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.organomet.9b00407. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79616 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉野 達彦
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