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Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice
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| Title: | Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice |
| Authors: | Sato, Keiichiro Browse this author | | Hamasaki, Yumi Browse this author | | Fukui, Kiyoshiro Browse this author | | Ito, Kazuki Browse this author | | Miyamichi, Kazunari Browse this author | | Minami, Masabumi Browse this author →KAKEN DB | | Amano, Taiju Browse this author →KAKEN DB |
| Keywords: | aggression | | amygdalohippocampal area | | medial preoptic area | | oxytocin | | rabies virus | | social behavior |
| Issue Date: | 13-May-2020 |
| Publisher: | Society for Neuroscience |
| Journal Title: | Journal of neuroscience |
| Volume: | 40 |
| Issue: | 20 |
| Start Page: | 3981 |
| End Page: | 3994 |
| Publisher DOI: | 10.1523/JNEUROSCI.0438-19.2020 |
| Abstract: | Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Here we focus on the amygdalohippocampal area (AHi) that projects to MPOA and expresses oxytocin receptor, a hormone receptor mediating social behavior toward pups. We describe the activation of MPOA-projection AHi neurons in male mice by social contact with pups. Input mapping using the TRIO method reveals that MPOA-projection AHi neurons receive prominent inputs from several regions, including the thalamus, hypothalamus, and olfactory cortex. Electrophysiological and histologic analysis demonstrates that oxytocin modulates inhibitory synaptic responses on MPOA-projection AHi neurons. In addition, AHi forms the excitatory monosynapse to MPOA, and pharmacological activation of MPOA-projection AHi neurons enhances only aggressive behavior, but not parental behavior. Interestingly, this promoted behavior was related to social experience in male mice. Collectively, our results identified a presynaptic partner of MPOA that can integrate sensory input and hormonal state, and trigger pup-directed aggression. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79739 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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