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Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice

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Title: Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice
Authors: Sato, Keiichiro Browse this author
Hamasaki, Yumi Browse this author
Fukui, Kiyoshiro Browse this author
Ito, Kazuki Browse this author
Miyamichi, Kazunari Browse this author
Minami, Masabumi Browse this author →KAKEN DB
Amano, Taiju Browse this author →KAKEN DB
Keywords: aggression
amygdalohippocampal area
medial preoptic area
rabies virus
social behavior
Issue Date: 13-May-2020
Publisher: Society for Neuroscience
Journal Title: Journal of neuroscience
Volume: 40
Issue: 20
Start Page: 3981
End Page: 3994
Publisher DOI: 10.1523/JNEUROSCI.0438-19.2020
Abstract: Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Here we focus on the amygdalohippocampal area (AHi) that projects to MPOA and expresses oxytocin receptor, a hormone receptor mediating social behavior toward pups. We describe the activation of MPOA-projection AHi neurons in male mice by social contact with pups. Input mapping using the TRIO method reveals that MPOA-projection AHi neurons receive prominent inputs from several regions, including the thalamus, hypothalamus, and olfactory cortex. Electrophysiological and histologic analysis demonstrates that oxytocin modulates inhibitory synaptic responses on MPOA-projection AHi neurons. In addition, AHi forms the excitatory monosynapse to MPOA, and pharmacological activation of MPOA-projection AHi neurons enhances only aggressive behavior, but not parental behavior. Interestingly, this promoted behavior was related to social experience in male mice. Collectively, our results identified a presynaptic partner of MPOA that can integrate sensory input and hormonal state, and trigger pup-directed aggression.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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