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A new SOBP-formation method by superposing specially shaped Bragg curves formed by a mini-ridge filter for spot scanning in proton beam therapy

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Title: A new SOBP-formation method by superposing specially shaped Bragg curves formed by a mini-ridge filter for spot scanning in proton beam therapy
Authors: Yokokawa, Kohei Browse this author
Furusaka, M. Browse this author
Matsuura, T. Browse this author
Hirayama, S. Browse this author
Umegaki, Kikuo Browse this author →KAKEN DB
Keywords: Spot-scanning proton therapy
Low-energy proton beam
Spread-out Bragg peak
Mini-ridge filter
Issue Date: Nov-2019
Publisher: Elsevier
Journal Title: Physica medica : European journal of medical physics
Volume: 67
Start Page: 70
End Page: 76
Publisher DOI: 10.1016/j.ejmp.2019.10.036
PMID: 31678799
Abstract: Purpose: We propose a new spread-out Bragg peak (SOBP) formation method for low-energy regions of spot-scanning proton therapy in order to reduce the required number of energy layers while maintaining high dose uniformity, while maintaining the distal falloff as sharp as possible. Methods: We use only one specially shaped mini-ridge filter (MRF) to create new trapezoidal Bragg curves (TBCs) from very sharp pristine Bragg curves (PBCs) of low-energy proton beams. The TBC has three pre-designed dose regions of proximal, flat-top, and distal components. These components are designed to have nearly equal depth lengths and good linearity. Then, the required SOBP is formed by superposing the TBCs with the correct spacing and beam intensity weights. We then compare the performance of the TBC-based SOBPs with those formed by PBCs. Results: The dose uniformities of the SOBP formed by the proposed method are kept within the design tolerance, and are equivalent to those of conventional SOBPs. The sharpness of the distal falloff is reasonably kept by the deepest TBC. The required number of energy layers is significantly reduced compared with that of conventional PBC-based SOBP. Conclusions: The proposed method enables shortening of the irradiation time of spot-scanning proton beam therapy in low-energy regions with a reduced number of energy layers. It can be realized by using only one specially shaped MRF, which can be easily installed at any facility.
Rights: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/79824
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 横川 航平

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