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Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

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Title: Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)
Authors: Wang, Yubo Browse this author
Quinsaat, Jose Enrico Q. Browse this author
Ono, Tomoko Browse this author
Maeki, Masatoshi Browse this author
Tokeshi, Manabu Browse this author →KAKEN DB
Isono, Takuya Browse this author
Tajima, Kenji Browse this author →KAKEN DB
Satoh, Toshifumi Browse this author →KAKEN DB
Sato, Shin-ichiro Browse this author →KAKEN DB
Miura, Yutaka Browse this author
Yamamoto, Takuya Browse this author →KAKEN DB
Issue Date: 30-Nov-2020
Publisher: Nature Research
Journal Title: Nature communications
Volume: 11
Issue: 1
Start Page: 6089
Publisher DOI: 10.1038/s41467-020-19947-8
Abstract: Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS-PEG-OMe). The stronger affinity of c-PEG was confirmed by DLS,.-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold-sulfur chemisorption.
Type: article
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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