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Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)
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Title: | Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol) |
Authors: | Wang, Yubo Browse this author | Quinsaat, Jose Enrico Q. Browse this author | Ono, Tomoko Browse this author | Maeki, Masatoshi Browse this author | Tokeshi, Manabu Browse this author →KAKEN DB | Isono, Takuya Browse this author | Tajima, Kenji Browse this author →KAKEN DB | Satoh, Toshifumi Browse this author →KAKEN DB | Sato, Shin-ichiro Browse this author →KAKEN DB | Miura, Yutaka Browse this author | Yamamoto, Takuya Browse this author →KAKEN DB |
Issue Date: | 30-Nov-2020 |
Publisher: | Nature Research |
Journal Title: | Nature communications |
Volume: | 11 |
Issue: | 1 |
Start Page: | 6089 |
Publisher DOI: | 10.1038/s41467-020-19947-8 |
Abstract: | Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS-PEG-OMe). The stronger affinity of c-PEG was confirmed by DLS,.-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold-sulfur chemisorption. |
Rights: | https://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/80639 |
Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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