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Overexpressed tumor protein p53 and the impaired function in aggressively growing calcifying odontogenic cyst: a case report

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Title: Overexpressed tumor protein p53 and the impaired function in aggressively growing calcifying odontogenic cyst: a case report
Authors: Ohiro, Yoichi Browse this author
Kakuguchi, Wataru Browse this author
Kuribayashi, Kazuyo Browse this author
Kitamura, Tetsuya Browse this author
Tei, Kanchu Browse this author
Keywords: Calcifying odontogenic cyst
Calcifying cystic odontogenic tumor
p53
MDM2
BAX
Issue Date: 15-Mar-2021
Publisher: 北海道歯学会
Journal Title: 北海道歯学雑誌
Volume: 41
Issue: 2
Start Page: 143
End Page: 146
Abstract: A case of a calcifying odontogenic cyst (COC) is described. The patient was referred to our hospital for the treatment of a recurrence of an ameloblastoma. To perform enucl eation as conservative surgery, deflation and biopsy were applied. From the specimens, the pathological diagnosis ha d changed to COC. After the biopsy, the lesions presented rapid growth and partial m axillectomy was performed. Morph ologically, malignant findings were not determined in the surgical specimens. To exclude the possibilit y of malignant transformation because of the rapid growth, an immunohistochemical analysis with cell growth marker Ki-67 and tumor suppressor p53 was performed, here a somewhat high positive staining of 10 % for Ki- 67 and 20-30 % for p53 were observed. To examine the metabolism and function of p53, further immunohistochemical staining was perfo rmed and showed negative staining for the p53 degradation enzyme MDM2 and positive staining of the p53-mediat ied apoptosis molecule BAX with 8 0 % positive staining. These findings suggest that the lesion had a high gro wth potential as well as abnormal p53 metabolism and function. Finally, COC was assigned as the pathological diagnos is giving priority to the morphological findings. No recurrence has been observed for 3 years after resection.
Type: article
URI: http://hdl.handle.net/2115/80691
Appears in Collections:北海道歯学雑誌 = Hokkaido Journal of Dental Science > 第41巻第2号

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