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Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice

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Title: Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice
Authors: Watanabe, Hiroshi Browse this author
Kuroki, Kimiko Browse this author →KAKEN DB
Yamada, Chisato Browse this author
Saburi, Yukari Browse this author
Maeda, Naoyoshi Browse this author →KAKEN DB
Maenaka, Katsumi Browse this author →KAKEN DB
Keywords: HLA-G2
Issue Date: Apr-2020
Publisher: Elsevier
Journal Title: Human immunology
Volume: 81
Issue: 4
Start Page: 186
End Page: 190
Publisher DOI: 10.1016/j.humimm.2019.11.002
Abstract: Human leukocyte antigen (HLA)-G, a non-classical HLA class I molecule, has one of the splicing isoforms, HLA-G2, which lacks one domain (alpha 2) and forms a non-covalent homodimer. HLA-G2 is expressed on placental cells, regulatory T cells, tumor cells, and virus-infected cells, and is involved in immunosuppression. The major isoform of HLA-G, HLA-G1, binds to leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2, on the contrary, HLA-G2 binds to only LILRB2. We previously reported that HLA-G2 bound LILRB2 more strongly than HLA-G1 and also to paired Ig-like receptor (PIR)-B, a mouse homolog of LILRBs. Furthermore, HLA-G2 showed immunosuppressive effects in both collagen-induced arthritis (CIA) and atopic dermatitis-like model mice. In this study, we examine in vivo effects of HLA-G2 in systemic lupus erythematosus (SLE) model mice. HLA-G2 showed the suppression of the typical SLE symptoms such as serum anti-dsDNA antibody level and urinary albumin index. Furthermore, HLA-G2 tended to downregulate B-lymphocyte stimulator (BLyS) production. This is the first observation of the immunosuppressive effects of HLA-G2 isoform in SLE model mice, suggesting that HLA-G2 could be a useful therapeutic agent for SLE.
Rights: ©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 黒木 喜美子

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