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Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate
| Title: | Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate |
| Authors: | Hashizume, Mei Browse this author | | Aoki, Koki Browse this author | | Ohno, Shigeaki Browse this author →KAKEN DB | | Kitaichi, Nobuyoshi Browse this author →KAKEN DB | | Yawata, Nobuyo Browse this author | | Gonzalez, Gabriel Browse this author | | Nonaka, Hirotaka Browse this author | | Sato, Seiichi Browse this author →KAKEN DB | | Takaoka, Akinori Browse this author →KAKEN DB |
| Keywords: | Human adenovirus | | epidemic keratoconjunctivitis | | disinfectants | | prevention | | RUBYSTA | | Virkon |
| Issue Date: | Mar-2021 |
| Publisher: | SAGE Publications |
| Journal Title: | European journal of ophthalmology |
| Volume: | 31 |
| Issue: | 2 |
| Start Page: | 379 |
| End Page: | 384 |
| Publisher DOI: | 10.1177/1120672119891408 |
| Abstract: | Purpose: The aim of this study was to test the antiviral effectivity of potassium peroxymonosulfate (RUBYSTA (R), KYORIN) against five epidemic keratoconjunctivitis-related types of Human adenovirus D in vitro. Methods: Five types of Human adenovirus D (8, 37, 53, 54 and 56) were incubated with 1% potassium peroxymonosulfate, 0.1% sodium hypochlorite (NaClO) or alcohol-based disinfectant for 30 s or 1 min. These solutions were subjected to measurements of viral titres by infection assays in A549 cells. At day 6 post-infection, both, supernatants and cells, were collected and the viral genome was assessed by real-time polymerase chain reaction analysis. Results: Treatments with 1% potassium peroxymonosulfate led to significant reduction in all tested Human adenovirus D types comparable to disinfecting effects by 0.1% NaClO. Overall, potassium peroxymonosulfate demonstrated sufficient inactivation of the major epidemic keratoconjunctivitis-causing Human adenovirus D to be considered for disinfection and prevention purposes in ophthalmological clinics and hospitals. Conclusion: This study demonstrated that potassium peroxymonosulfate is a promising disinfectant for the prevention of epidemic keratoconjunctivitis nosocomial infections in ophthalmological clinics. |
| Rights: | Mei Hashizume, Koki Aoki, Shigeaki Ohno, Nobuyoshi Kitaichi, Nobuyo Yawata, Gabriel Gonzalez, Hirotaka Nonaka, Seiichi Sato, Akinori Takaoka, Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate Show less, European Journal of Ophthalmology Vol. 31(2) pp. 379-384. Copyright ©2021 (Copyright Holder). DOI:10.1177/1120672119891408 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/81697 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高岡 晃教
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