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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Information Science and Technology / Faculty of Information Science and Technology >
Peer-reviewed Journal Articles, etc >
Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance
| Title: | Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance |
| Authors: | Kimura, Kota Browse this author | | Iguchi, Nami Browse this author | | Nakano, Hitomi Browse this author | | Yasui, Hironobu Browse this author →KAKEN DB | | Matsumoto, Shingo Browse this author →KAKEN DB | | Inanami, Osamu Browse this author →KAKEN DB | | Hirata, Hiroshi Browse this author →KAKEN DB |
| Keywords: | redox-sensitive mapping | | electron paramagnetic resonance | | nitroxyl radical | | compressed sensing | | mouse xenograft model |
| Issue Date: | 23-Jun-2021 |
| Publisher: | Mary Ann Liebert |
| Journal Title: | Antioxidants & redox signaling |
| Volume: | 36 |
| Issue: | 1-3 |
| Start Page: | 57 | | 69 |
| Publisher DOI: | 10.1089/ars.2021.0003 |
| Abstract: | Aims: This work aimed to establish an accelerated imaging system for redox-sensitive mapping in a mouse tumor model using electron paramagnetic resonance (EPR) and nitroxyl radicals. Results: Sparse sampling of EPR spectral projections was demonstrated for a solution phantom. The reconstructed three-dimensional (3D) images with filtered back-projection (FBP) and compressed sensing image reconstruction were quantitatively assessed for the solution phantom. Mouse xenograft models of a human-derived pancreatic ductal adenocarcinoma cell line, MIA PaCa-2, were also measured for redox-sensitive mapping with the sparse sampling technique. Innovation: A short-lifetime redox-sensitive nitroxyl radical (N-15-labeled perdeuterated Tempone) could be measured to map the decay rates of the EPR signals for the mouse xenograft models. Acceleration of 3D EPR image acquisition broadened the choices of nitroxyl radical probes with various redox sensitivities to biological environments. Conclusion: Sparse sampling of EPR spectral projections accelerated image acquisition in the 3D redox-sensitive mapping of mouse tumor-bearing legs fourfold compared with conventional image acquisition with FBP. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81997 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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