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Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

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Title: Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance
Authors: Kimura, Kota Browse this author
Iguchi, Nami Browse this author
Nakano, Hitomi Browse this author
Yasui, Hironobu Browse this author →KAKEN DB
Matsumoto, Shingo Browse this author →KAKEN DB
Inanami, Osamu Browse this author →KAKEN DB
Hirata, Hiroshi Browse this author →KAKEN DB
Keywords: redox-sensitive mapping
electron paramagnetic resonance
nitroxyl radical
compressed sensing
mouse xenograft model
Issue Date: 23-Jun-2021
Publisher: Mary Ann Liebert
Journal Title: Antioxidants & redox signaling
Publisher DOI: 10.1089/ars.2021.0003
Abstract: Aims: This work aimed to establish an accelerated imaging system for redox-sensitive mapping in a mouse tumor model using electron paramagnetic resonance (EPR) and nitroxyl radicals. Results: Sparse sampling of EPR spectral projections was demonstrated for a solution phantom. The reconstructed three-dimensional (3D) images with filtered back-projection (FBP) and compressed sensing image reconstruction were quantitatively assessed for the solution phantom. Mouse xenograft models of a human-derived pancreatic ductal adenocarcinoma cell line, MIA PaCa-2, were also measured for redox-sensitive mapping with the sparse sampling technique. Innovation: A short-lifetime redox-sensitive nitroxyl radical (N-15-labeled perdeuterated Tempone) could be measured to map the decay rates of the EPR signals for the mouse xenograft models. Acceleration of 3D EPR image acquisition broadened the choices of nitroxyl radical probes with various redox sensitivities to biological environments. Conclusion: Sparse sampling of EPR spectral projections accelerated image acquisition in the 3D redox-sensitive mapping of mouse tumor-bearing legs fourfold compared with conventional image acquisition with FBP.
Type: article
URI: http://hdl.handle.net/2115/81997
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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