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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Prognostic role of H3K27M mutation, histone H3K27 methylation status, and EZH2 expression in diffuse spinal cord gliomas
| Title: | Prognostic role of H3K27M mutation, histone H3K27 methylation status, and EZH2 expression in diffuse spinal cord gliomas |
| Authors: | Ishi, Yukitomo Browse this author →KAKEN DB | | Takamiya, Soichiro Browse this author | | Seki, Toshitaka Browse this author | | Yamazaki, Kazuyoshi Browse this author | | Hida, Kazutoshi Browse this author →KAKEN DB | | Hatanaka, Kanako C. Browse this author | | Ishida, Yusuke Browse this author →KAKEN DB | | Oda, Yoshitaka Browse this author | | Tanaka, Shinya Browse this author →KAKEN DB | | Yamaguchi, Shigeru Browse this author |
| Keywords: | Spinal cord | | Glioma | | EZH2 |
| Issue Date: | Jul-2021 |
| Publisher: | Springer |
| Journal Title: | Brain Tumor Pathology |
| Volume: | 37 |
| Issue: | 3 |
| Start Page: | 81 |
| End Page: | 88 |
| Publisher DOI: | 10.1007/s10014-020-00369-9 |
| Abstract: | The objective of this study is to clarify clinical significance of theH3F3A K27Mmutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwent genetic analysis forH3F3A, HIST1H3B,TERTpromoter,IDH1/2, andBRAF. H3K27me3 status and EZH2 expression were analyzed through immunohistochemistry. Thereafter, the association between H3K27M, H3K27me3 status, and EZH2 expression and prognosis was retrospectively analyzed using the log-rank test. A total of 26 cases, 5 with WHO grade 4, 9 with grade 3, and 12 with grade 2 glioma, were analyzed. Although WHO grade 2 cases tended to present favorable overall survival, the difference was not statistically significant. H3K27M, which was detected in four grade 4 cases (80%) and three grade 3 cases (33%), was not associated with prognosis among grade 3 and 4 cases. Among WHO grade 2-4 cases, the combination of retained H3K27me3 and negative EZH2 expression was correlated with favorable overall survival (p = 0.03). The combination of H3K27me3 status and EZH2 expression was considered as a potential prognostic marker in WHO grade 2-4 diffuse spinal cord gliomas. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Brain Tumor Pathology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10014-020-00369-9 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/82148 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 伊師 雪友
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