HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Associations between cognitive impairment and P300 mean amplitudes in individuals with bipolar disorder in remission

This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Files in This Item:
COBRA P300 HUSCAP_manuscript.pdf246.46 kBPDFView/Open
COBRA P300 HUSCAP_suppl..docx78.89 kBMicrosoft Word XMLView/Open
Please use this identifier to cite or link to this item:

Title: Associations between cognitive impairment and P300 mean amplitudes in individuals with bipolar disorder in remission
Authors: Toyoshima, Kuniyoshi Browse this author →KAKEN DB
Toyomaki, Atsuhito Browse this author →KAKEN DB
Miyazaki, Akane Browse this author
Martinez-Aran, Anabel Browse this author
Vieta, Eduard Browse this author
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Cognitive complaints
Cognitive function
Neuropsychological assessment
Issue Date: Aug-2020
Publisher: Elsevier
Journal Title: Psychiatry research
Volume: 290
Start Page: 113125
Publisher DOI: 10.1016/j.psychres.2020.113125
Abstract: Cognitive functions are often affected during the euthymic state of bipolar disorder (BD). In this study, we investigated the associations among cognitive complaints, objective cognitive functions, and the mean amplitudes of the P300 event-related potential (ERP) wave in individuals with BD. The study population comprised 33 individuals with BD who were in remission and was conducted at Hokkaido University Hospital, Sapporo, Japan. Cognitive complaints were assessed using the Japanese version of the tool named "cognitive complaints in bipolar disorder rating assessment (COBRA)", whereas objective cognitive functions were measured by neuropsychological tests. P300 mean amplitudes were investigated during two- and three-stimulus oddball tasks and showed significant correlations with neuropsychological test scores at all electrode locations, confirming that ERPs and objective cognitive tests that assessed attention and memory function tend to coincide; however, neither P300 amplitudes nor neuropsychological test scores were correlated with COBRA scores. ERPs most likely represent the neurophysiological basis for objective rather than subjective cognitive function in euthymic individuals. Thus, our results suggest that objective cognitive function is related more to P300 mean amplitude scores than subjective cognitive function in individuals with BD.
Rights: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 豊島 邦義

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University