|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart
| Title: | Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart |
| Authors: | El-Far, Ali H. Browse this author | | Elewa, Yaser H. A. Browse this author | | Abdelfattah, Elsayeda-Zeinab A. Browse this author | | Alsenosy, Abdel-Wahab A. Browse this author | | Atta, Mustafa S. Browse this author | | Abou-Zeid, Khalid M. Browse this author | | Al Jaouni, Soad K. Browse this author | | Mousa, Shaker A. Browse this author | | Noreldin, Ahmed E. Browse this author |
| Keywords: | thymoquinone | | curcumin | | D-galactose | | oxidative stress | | anti-aging |
| Issue Date: | 1-Jul-2021 |
| Publisher: | MDPI |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 22 |
| Issue: | 13 |
| Start Page: | 6839 |
| Publisher DOI: | 10.3390/ijms22136839 |
| Abstract: | D-galactose (D-gal) administration causes oxidative disorder and is widely utilized in aging animal models. Therefore, we subcutaneously injected D-gal at 200 mg/kg BW dose to assess the potential preventive effect of thymoquinone (TQ) and curcumin (Cur) against the oxidative alterations induced by D-gal. Other than the control, vehicle, and D-gal groups, the TQ and Cur treated groups were orally supplemented at 20 mg/kg BW of each alone or combined. TQ and Cur effectively suppressed the oxidative alterations induced by D-gal in brain and heart tissues. The TQ and Cur combination significantly decreased the elevated necrosis in the brain and heart by D-gal. It significantly reduced brain caspase 3, calbindin, and calcium-binding adapter molecule 1 (IBA1), heart caspase 3, and BCL2. Expression of mRNA of the brain and heart TP53, p21, Bax, and CASP-3 were significantly downregulated in the TQ and Cur combination group along with upregulation of BCL2 in comparison with the D-gal group. Data suggested that the TQ and Cur combination is a promising approach in aging prevention. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82385 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
