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A cross-sectional exploratory survey on occurrence of triple-whammy prescription pattern in Japan

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/82453

Title: A cross-sectional exploratory survey on occurrence of triple-whammy prescription pattern in Japan
Authors: Imai, Shungo Browse this author →KAKEN DB
Momo, Kenji Browse this author
Kashiwagi, Hitoshi Browse this author →KAKEN DB
Miyai, Takayuki Browse this author
Sugawara, Mitsuru Browse this author →KAKEN DB
Takekuma, Yoh Browse this author →KAKEN DB
Keywords: Acute kidney injury
Insurance claims
Japan
Triple-whammy prescriptions
Issue Date: 17-Aug-2020
Publisher: Springer
Journal Title: International Journal of Clinical Pharmacy
Volume: 42
Start Page: 1369
End Page: 1373
Publisher DOI: 10.1007/s11096-020-01088-z
Abstract: BackgroundThe concurrent use of nonsteroidal anti-inflammatory drugs, renin-angiotensin-aldosterone system blockers, and diuretics, known as a "triple-whammy," is related to the occurrence of acute kidney injury. However, there are few reports regarding the prescription pattern of the triple-whammy.ObjectiveTo elucidate the patterns of the triple-whammy prescription in Japan.MethodsA cross-sectional study was performed using a health-insurance-claims database that included Japanese people under 75 years of age, and enrolled outpatients that were prescribed any nonsteroidal anti-inflammatory drugs, renin-angiotensin-aldosterone system blockers, and diuretics between April 2017 and June 2017. As an outcome, the proportion of triple-whammy prescriptions was evaluated. Among the patients who received triple-whammy prescriptions, we evaluated the prevalence of chronic kidney disease and the proportion of prescriptions provided for these three drugs from different clinical departments and institutions.ResultsOverall, 730 of 246,721 (0.3%) patients received triple-whammy prescriptions. Among these patients, 13.3% had underlying chronic kidney disease. The proportions of any of the three drug types prescribed by different clinical departments and institutions was 48.2% and 61.8%, respectively.ConclusionsWe examined the patterns of triple-whammy prescriptions and concluded that pharmacists need to pay attention to triple-whammy prescriptions if the prescriptions are provided by multiple clinical departments or institutions.
Rights: This is a post-peer-review, pre-copyedit version of an article published in International Journal of Clinical Pharmacy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11096-020-01088-z.
Type: article (author version)
URI: http://hdl.handle.net/2115/82453
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 今井 俊吾

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