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Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction

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Title: Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction
Authors: Yamada, Takahiro Browse this author →KAKEN DB
Takao, Seishin Browse this author →KAKEN DB
Koyano, Hidenori Browse this author
Nihongi, Hideaki Browse this author
Fujii, Yusuke Browse this author
Hirayama, Shusuke Browse this author
Miyamoto, Naoki Browse this author →KAKEN DB
Matsuura, Taeko Browse this author →KAKEN DB
Umegaki, Kikuo Browse this author →KAKEN DB
Katoh, Norio Browse this author →KAKEN DB
Yokota, Isao Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Keywords: proton therapy
spot scanning
log data
dose reconstruction
motion management
Issue Date: Jul-2021
Publisher: Oxford University Press
Journal Title: Journal of Radiation Research
Volume: 62
Issue: 4
Start Page: 626
End Page: 633
Publisher DOI: 10.1093/jrr/rrab024
Abstract: In spot scanning proton therapy (SSPT), the spot position relative to the target may fluctuate through tumor motion even when gating the radiation by utilizing a fiducial marker. We have established a procedure that evaluates the delivered dose distribution by utilizing log data on tumor motion and spot information. The purpose of this study is to show the reliability of the dose distributions for liver tumors treated with real-time-image gated SSPT (RGPT). In the evaluation procedure, the delivered spot information and the marker position are synchronized on the basis of log data on the timing of the spot irradiation and fluoroscopic X-ray irradiation. Then a treatment planning system reconstructs the delivered dose distribution. Dose distributions accumulated for all fractions were reconstructed for eight liver cases. The log data were acquired in all 168 fractions for all eight cases. The evaluation was performed for the values of maximum dose, minimum dose, D99, and D5-D95 for the clinical target volumes (CTVs) and mean liver dose (MLD) scaled by the prescribed dose. These dosimetric parameters were statistically compared between the planned dose distribution and the reconstructed dose distribution. The mean difference of the maximum dose was 1.3% (95% confidence interval [CI]: 0.6%-2.1%). Regarding the minimum dose, the mean difference was 0.1% (95% CI: -0.5%-0.7%). The mean differences of D99, D5-D95 and MLD were below 1%. The reliability of dose distributions for liver tumors treated with RGPT-SSPT was shown by the evaluation of the accumulated dose distributions.
Type: article
URI: http://hdl.handle.net/2115/82679
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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