Title: | Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction |
Authors: | Yamada, Takahiro Browse this author →KAKEN DB |
Takao, Seishin Browse this author →KAKEN DB |
Koyano, Hidenori Browse this author |
Nihongi, Hideaki Browse this author |
Fujii, Yusuke Browse this author |
Hirayama, Shusuke Browse this author |
Miyamoto, Naoki Browse this author →KAKEN DB |
Matsuura, Taeko Browse this author →KAKEN DB |
Umegaki, Kikuo Browse this author →KAKEN DB |
Katoh, Norio Browse this author →KAKEN DB |
Yokota, Isao Browse this author →KAKEN DB |
Shirato, Hiroki Browse this author →KAKEN DB |
Shimizu, Shinichi Browse this author →KAKEN DB |
Keywords: | proton therapy |
spot scanning |
log data |
dose reconstruction |
motion management |
Issue Date: | Jul-2021 |
Publisher: | Oxford University Press |
Journal Title: | Journal of Radiation Research |
Volume: | 62 |
Issue: | 4 |
Start Page: | 626 |
End Page: | 633 |
Publisher DOI: | 10.1093/jrr/rrab024 |
Abstract: | In spot scanning proton therapy (SSPT), the spot position relative to the target may fluctuate through tumor motion even when gating the radiation by utilizing a fiducial marker. We have established a procedure that evaluates the delivered dose distribution by utilizing log data on tumor motion and spot information. The purpose of this study is to show the reliability of the dose distributions for liver tumors treated with real-time-image gated SSPT (RGPT). In the evaluation procedure, the delivered spot information and the marker position are synchronized on the basis of log data on the timing of the spot irradiation and fluoroscopic X-ray irradiation. Then a treatment planning system reconstructs the delivered dose distribution. Dose distributions accumulated for all fractions were reconstructed for eight liver cases. The log data were acquired in all 168 fractions for all eight cases. The evaluation was performed for the values of maximum dose, minimum dose, D99, and D5-D95 for the clinical target volumes (CTVs) and mean liver dose (MLD) scaled by the prescribed dose. These dosimetric parameters were statistically compared between the planned dose distribution and the reconstructed dose distribution. The mean difference of the maximum dose was 1.3% (95% confidence interval [CI]: 0.6%-2.1%). Regarding the minimum dose, the mean difference was 0.1% (95% CI: -0.5%-0.7%). The mean differences of D99, D5-D95 and MLD were below 1%. The reliability of dose distributions for liver tumors treated with RGPT-SSPT was shown by the evaluation of the accumulated dose distributions. |
Type: | article |
URI: | http://hdl.handle.net/2115/82679 |
Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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