HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >

An organocatalytic ring-opening polymerization approach to highly alternating copolymers of lactic acid and glycolic acid

Files in This Item:
main text_rev2 (Isono).pdf788.61 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: An organocatalytic ring-opening polymerization approach to highly alternating copolymers of lactic acid and glycolic acid
Authors: Takojima, Kaoru Browse this author
Makino, Hiroshi Browse this author
Saito, Tatsuya Browse this author
Yamamoto, Takuya Browse this author
Tajima, Kenji Browse this author →KAKEN DB
Isono, Takuya Browse this author
Satoh, Toshifumi Browse this author →KAKEN DB
Issue Date: 21-Oct-2020
Publisher: Royal Society of Chemistry
Journal Title: Polymer chemistry
Volume: 11
Issue: 39
Start Page: 6365
End Page: 6373
Publisher DOI: 10.1039/d0py01082k
Abstract: The alternating copolymer of lactic acid and glycolic acid (PLGA) is a highly promising next generation biodegradable material for biomedical and pharmaceutical applications due to its uniform degradation behaviors in addition to its ability to form stereocomplexes. However, versatile synthetic methods toward the narrowly dispersed alternating PLGAs with controlled molecular weights and desired end functionalities have been largely unexplored. Herein, we report the organocatalytic regioselective ring-opening polymerization (ROP) of optically active methylglycolides (l- andd-MGs) to produce highly alternating PLGAs. The ROP ofl-MG using a phosphazene base P-2-t-Bu/alcohol system in THF at -78 degrees C achieved the highest regioselectivity (P= 0.95) as well as a good control over the molecular weight (M-n= 6.6-15.6 g mol(-1)), with a relatively narrow dispersity (D= 1.21-1.29). Furthermore, alternating PLGA diol as well as azido-, ethynyl-, and poly(ethylene glycol) monomethyl ether-end-functionalized alternating PLGAs was successfully obtained by employing the corresponding functional alcohol initiators. An enantiomeric 1 : 1 blend of PLGAs prepared froml- andd-MGs formed a stereocomplex with a crystallinity and melting point comparable to the reported data for the stereocomplex from the perfectly alternating PLGAs producedviaa polycondensation approach, which implies the high degree of the alternating sequence of the obtained copolymers.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 磯野 拓也

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University