Rhodium(III)/Chiral Carboxylic Acid Catalyzed Enantioselective C(sp(3))-H Alkylation of 8-Ethylquinolines with alpha,beta-Unsaturated Carbonyl Compounds

Huang, Long-Tao; Fukagawa, Seiya; Kojima, Masahiro; Yoshino, Tatsuhiko; Matsunaga, Shigeki

doi:10.1021/acs.orglett.0c02872


Hokkaido University \| Library \| HUSCAP	Advanced Search		言語

	Home
	About HUSCAP
	Open Access Policy

	Browse by Author

Browse
	Communities & Collections

	Scholarly Journals
	Theses
	Doctoral Dissertations Listed by Graduate Schools
	Conference Procs.
	Events

	HUSCAP Senior (in Japanese)

	Societies

	Downloads (country)

For university staff
	How to post your papers to HUSCAP
	Publication of theses
	Helpline about theses publication

Open Archives Compliant

You can search our collection also at:
	Google
	Google Scholar
	CiNii
	IRDB
	OAIster
	NDLTD

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Rhodium(III)/Chiral Carboxylic Acid Catalyzed Enantioselective C(sp(3))-H Alkylation of 8-Ethylquinolines with alpha,beta-Unsaturated Carbonyl Compounds

Files in This Item:

WoS_96847_Yoshino.pdf

725.77 kB

PDF

View/Open

Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/83205

Title:	Rhodium(III)/Chiral Carboxylic Acid Catalyzed Enantioselective C(sp(3))-H Alkylation of 8-Ethylquinolines with alpha,beta-Unsaturated Carbonyl Compounds
Authors:	Huang, Long-Tao Browse this author
	Fukagawa, Seiya Browse this author
	Kojima, Masahiro Browse this author →KAKEN DB
	Yoshino, Tatsuhiko Browse this author →KAKEN DB
	Matsunaga, Shigeki Browse this author →KAKEN DB
Issue Date:	6-Nov-2020
Publisher:	American Chemical Society
Journal Title:	Organic letters
Volume:	22
Issue:	21
Start Page:	8256
End Page:	8260
Publisher DOI:	10.1021/acs.orglett.0c02872
PMID:	33064493
Abstract:	The enantioselective C-H alkylation of 8-ethylquinolines with enones or acrolein using a Rh-III catalyst and a chiral carboxylic acid is described. Under mild reaction conditions, a binaphthyl-based chiral carboxylic acid enables the enantioselective cleavage of the 8-ethylquinoline C(sp(3))-H bond. The obtained results demonstrate the utility of the combination of a high-valent group 9 metal catalyst and a chiral carboxylic acid for the enantioselective C(sp(3))-H activation and the subsequent C-C bond formation.
Rights:	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic letters, copyright c American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.0c02872.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/83205
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉野達彦

OAI-PMH ( junii2 , jpcoar_1.0 )

- Hokkaido University