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Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23
| Title: | Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23 |
| Authors: | Suzuki, Hiroe Browse this author | | Otsuka, Takahisa Browse this author | | Hitora-Imamura, Natsuko Browse this author | | Ishimura, Kohei Browse this author | | Fukuda, Hayato Browse this author | | Fujiwara, Koichi Browse this author →KAKEN DB | | Shuto, Satoshi Browse this author →KAKEN DB | | Deyama, Satoshi Browse this author →KAKEN DB | | Minami, Masabumi Browse this author →KAKEN DB |
| Keywords: | resolvin | | n-3 polyunsaturated fatty acid | | antidepressant | | pain |
| Issue Date: | 1-Oct-2021 |
| Publisher: | The Pharmaceutical Society of Japan （日本薬学会） |
| Journal Title: | Biological & pharmaceutical bulletin |
| Volume: | 44 |
| Issue: | 10 |
| Start Page: | 1548 |
| End Page: | 1550 |
| Publisher DOI: | 10.1248/bpb.b21-00461 |
| Abstract: | The antidepressant effect of eicosapentaenoic acid-derived bioactive lipid, resolvin E1 (RvE1), was examined in a murine model of chronic pain-induced depression using a tail suspension test. Because RvE1 reportedly possesses agonistic activity on a chemerin receptor ChemR23, we also examined the antidepressant effect of chemerin. Two weeks after surgery for unilateral spared nerve injury to prepare neuropathic pain model mice, immobility time was measured in a tail suspension test. Chronic pain significantly increased immobility time, and this depression-like behavior was attenuated by intracerebroventricular injection of RvE1 (1 ng) or chemerin (500 ng). These results demonstrate that RvE1 exerts an antidepressant effect in a murine model of chronic pain-induced depression, which is likely to be via ChemR23. RvE1 and its receptor may be promising targets to develop novel antidepressants. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83324 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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