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Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans

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Title: Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans
Authors: Wakabayashi, Hitoshi Browse this author
Matsumoto, Kentaro Browse this author
Kobori, Yusuke Browse this author
Ebara, Tasuku Browse this author
Matsushita, Mami Browse this author
Kameya, Toshimitsu Browse this author
Maeda, Takafumi Browse this author
Saito, Masayuki Browse this author →KAKEN DB
Keywords: Brown adipose tissue
Skeletal muscle
Cold-induced thermogenesis
Whole-body contribution
Issue Date: Dec-2020
Publisher: Springer
Journal Title: European journal of applied physiology
Volume: 120
Issue: 12
Start Page: 2737
End Page: 2747
Publisher DOI: 10.1007/s00421-020-04496-1
Abstract: Purpose Human brown adipose tissue (BAT) is known to be a significant thermoeffector in non-shivering thermogenesis (NST), albeit with individual variations in the BAT activity. We hypothesized that humans with less BAT would have more contribution from the skeletal muscle (SM) to NST or earlier shivering onset and greater vasoconstriction to compensate for less BAT-mediated thermogenesis. Methods Eighteen males participated in this study. Their BAT activity and detectable volume were investigated. A gradual cold exposure was conducted for inducing NST at 18.6 degrees C and initiating shivering at 11.6 degrees C. The energy expenditure, electromyograph of the pectoralis major, skin blood flow, and rectal (T-re) and skin temperatures were evaluated. Results BAT volume significantly correlated with the change in metabolic heat production during mild cold phase relative to baseline (NST;r = 0.562,P < 0.05), but not with shivering initiation phase (NST+ ST). SM mass correlated with baseline metabolic heat production (M-base;r = 0.839,P < 0.01) but not withNSTorNST + ST. A positive correlation was noted between BAT volume andT(re)at the end of the 18.6 degrees C exposure period (r = 0.586,P < 0.05), which positively correlated with shivering onset time (r = 0.553,P < 0.05). The skin blood flow, mean skin temperature, and forearm and finger skin temperature difference at the end of the 18.6 degrees C exposure period did not correlate withNSTor BAT volume. Conclusion BAT volume positively correlated withNST. Notably, lowerT(re)in individuals with less BAT volume induced earlier shivering onset for offsetting the lessNST. Whereas, no correlation between metabolic and vasomotor responses was observed.
Rights: This is a post-peer-review, pre-copyedit version of an article published in European Journal of Applied Physiology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 若林 斉

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