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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >
Deformation of microtubules regulates translocation dynamics of kinesin
| Title: | Deformation of microtubules regulates translocation dynamics of kinesin |
| Authors: | Nasrin, Syeda Rubaiya Browse this author | | Ganser, Christian Browse this author | | Nishikawa, Seiji Browse this author | | Kabir, Arif Md Rashedul Browse this author | | Sada, Kazuki Browse this author | | Yamashita, Takefumi Browse this author | | Ikeguchi, Mitsunori Browse this author | | Uchihashi, Takayuki Browse this author | | Hess, Henry Browse this author | | Kakugo, Akira Browse this author →KAKEN DB |
| Issue Date: | Oct-2021 |
| Publisher: | The American Association for the Advancement of Science（AAAS） |
| Journal Title: | Science advances |
| Volume: | 7 |
| Issue: | 42 |
| Start Page: | eabf2211 |
| Publisher DOI: | 10.1126/sciadv.abf2211 |
| Abstract: | Microtubules, the most rigid components of the cytoskeleton, can be key transduction elements between external forces and the cellular environment. Mechanical forces induce microtubule deformation, which is presumed to be critical for the mechanoregulation of cellular events. However, concrete evidence is lacking. In this work, with high-speed atomic force microscopy, we unravel how microtubule deformation regulates the translocation of the microtubule-associated motor protein kinesin-1, responsible for intracellular transport. Our results show that the microtubule deformation by bending impedes the translocation dynamics of kinesins along them. Molecular dynamics simulation shows that the hindered translocation of kinesins can be attributed to an enhanced affinity of kinesins to the microtubule structural units in microtubules deformed by bending. This study advances our understanding of the role of cytoskeletal components in mechanotransduction. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83434 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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