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Deformation of microtubules regulates translocation dynamics of kinesin

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Title: Deformation of microtubules regulates translocation dynamics of kinesin
Authors: Nasrin, Syeda Rubaiya Browse this author
Ganser, Christian Browse this author
Nishikawa, Seiji Browse this author
Kabir, Arif Md Rashedul Browse this author
Sada, Kazuki Browse this author
Yamashita, Takefumi Browse this author
Ikeguchi, Mitsunori Browse this author
Uchihashi, Takayuki Browse this author
Hess, Henry Browse this author
Kakugo, Akira Browse this author →KAKEN DB
Issue Date: Oct-2021
Publisher: The American Association for the Advancement of Science(AAAS)
Journal Title: Science advances
Volume: 7
Issue: 42
Start Page: eabf2211
Publisher DOI: 10.1126/sciadv.abf2211
Abstract: Microtubules, the most rigid components of the cytoskeleton, can be key transduction elements between external forces and the cellular environment. Mechanical forces induce microtubule deformation, which is presumed to be critical for the mechanoregulation of cellular events. However, concrete evidence is lacking. In this work, with high-speed atomic force microscopy, we unravel how microtubule deformation regulates the translocation of the microtubule-associated motor protein kinesin-1, responsible for intracellular transport. Our results show that the microtubule deformation by bending impedes the translocation dynamics of kinesins along them. Molecular dynamics simulation shows that the hindered translocation of kinesins can be attributed to an enhanced affinity of kinesins to the microtubule structural units in microtubules deformed by bending. This study advances our understanding of the role of cytoskeletal components in mechanotransduction.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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