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Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner

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Title: Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner
Authors: Hayase, Shin Browse this author
Shao, Chengru Browse this author
Kobayashi, Masahiko Browse this author
Mori, Chihiro Browse this author
Liu, Wan-Chun Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Keywords: Song learning
Sensorimotor learning
Learning plasticity
Critical period
Issue Date: 29-Oct-2021
Publisher: BioMed Central
Journal Title: Molecular brain
Volume: 14
Issue: 1
Start Page: 160
Publisher DOI: 10.1186/s13041-021-00869-5
Abstract: Songbirds are one of the few animal taxa that possess vocal learning abilities. Different species of songbirds exhibit species-specific learning programs during song acquisition. Songbirds with open-ended vocal learning capacity, such as the canary, modify their songs during adulthood. Nevertheless, the neural molecular mechanisms underlying open-ended vocal learning are not fully understood. We investigated the singing-driven expression of neural activity-dependent genes (Arc, Egr1, c-fos, Nr4a1, Sik1, Dusp6, and Gadd45 beta) in the canary to examine a potential relationship between the gene expression level and the degree of seasonal vocal plasticity at different ages. The expression of these genes was differently regulated throughout the critical period of vocal learning in the zebra finch, a closed-ended song learner. In the canary, the neural activity-dependent genes were induced by singing in the song nuclei throughout the year. However, in the vocal motor nucleus, the robust nucleus of the arcopallium (RA), all genes were regulated with a higher induction rate by singing in the fall than in the spring. The singing-driven expression of these genes showed a similar induction rate in the fall between the first year juvenile and the second year adult canaries, suggesting a seasonal, not age-dependent, regulation of the neural activity-dependent genes. By measuring seasonal vocal plasticity and singing-driven gene expression, we found that in RA, the induction intensity of the neural activity-dependent genes was correlated with the state of vocal plasticity. These results demonstrate a correlation between vocal plasticity and the singing-driven expression of neural activity-dependent genes in RA through song development, regardless of whether a songbird species possesses an open- or closed-ended vocal learning capacity.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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