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Peer-reviewed Journal Articles, etc >
Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials
| Title: | Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials |
| Authors: | Pang, Yadong Browse this author | | Lee, Joo Won Browse this author | | Kubota, Koji Browse this author | | Ito, Hajime Browse this author →KAKEN DB |
| Keywords: | C-H trifluoromethylation | | mechanochemistry | | radical reactions | | solid-state reactions | | synthetic methods |
| Issue Date: | 7-Dec-2020 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Angewandte chemie-international edition |
| Volume: | 59 |
| Issue: | 50 |
| Start Page: | 22570 |
| End Page: | 22576 |
| Publisher DOI: | 10.1002/anie.202009844 |
| Abstract: | The application of piezoelectricity for the generation of trifluoromethyl (CF3) radicals is reported together with the development of a method for the mechanochemical C-H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C-H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science. |
| Rights: | This is the peer reviewed version of the following article: Y. Pang, J. W. Lee, K. Kubota, H. Ito, Angew. Chem. Int. Ed. 2020, 59, 22570. , which has been published in final form at https://doi.org/10.1002/anie.202009844. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/83448 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 久保田 浩司
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