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Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials

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Title: Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials
Authors: Pang, Yadong Browse this author
Lee, Joo Won Browse this author
Kubota, Koji Browse this author
Ito, Hajime Browse this author →KAKEN DB
Keywords: C-H trifluoromethylation
radical reactions
solid-state reactions
synthetic methods
Issue Date: 7-Dec-2020
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie-international edition
Volume: 59
Issue: 50
Start Page: 22570
End Page: 22576
Publisher DOI: 10.1002/anie.202009844
Abstract: The application of piezoelectricity for the generation of trifluoromethyl (CF3) radicals is reported together with the development of a method for the mechanochemical C-H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C-H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.
Rights: This is the peer reviewed version of the following article: Y. Pang, J. W. Lee, K. Kubota, H. Ito, Angew. Chem. Int. Ed. 2020, 59, 22570. , which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久保田 浩司

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