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Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/8407

Title: Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
Authors: Sato, Noriko Browse this author
Kamada, Nobuyuki Browse this author
Muromoto, Ryuta Browse this author
Kawai, Taro Browse this author
Sugiyama, Kenji Browse this author
Watanabe, Tadashi Browse this author
Imoto, Seiyu Browse this author
Sekine, Yuichi Browse this author
Ohbayashi, Norihiko Browse this author
Ishida, Masato Browse this author
Akira, Shizuo Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: ZIPK
IL-6
LIF
apoptosis
phosphorylation
Issue Date: 15-Mar-2006
Publisher: Elsevier
Journal Title: Immunology Letters
Volume: 103
Issue: 2
Start Page: 127
End Page: 134
Publisher DOI: 10.1016/j.imlet.2005.10.015
PMID: 16325270
Abstract: Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses revealed that autophosphorylation of Thr265 was essential for its full catalytic activity toward an exogenous substrate as well as for cell death induction. Furthermore, leukemia inhibitory factor (LIF) stimulated Thr265 phosphorylation of ZIPK, thereby leading to phosphorylation and activation of signal transducer and activator of transcription (STAT3). Taken together, our findings demonstrate that ZIPK is positively regulated through Thr265 phosphorylation and that this phosphorylation is essential for its function.
Relation: http://www.sciencedirect.com/science/journal/01652478
Type: article (author version)
URI: http://hdl.handle.net/2115/8407
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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