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Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
| Title: | Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines |
| Authors: | Sato, Noriko Browse this author | | Kamada, Nobuyuki Browse this author | | Muromoto, Ryuta Browse this author | | Kawai, Taro Browse this author | | Sugiyama, Kenji Browse this author | | Watanabe, Tadashi Browse this author | | Imoto, Seiyu Browse this author | | Sekine, Yuichi Browse this author | | Ohbayashi, Norihiko Browse this author | | Ishida, Masato Browse this author | | Akira, Shizuo Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | ZIPK | | IL-6 | | LIF | | apoptosis | | phosphorylation |
| Issue Date: | 15-Mar-2006 |
| Publisher: | Elsevier |
| Journal Title: | Immunology Letters |
| Volume: | 103 |
| Issue: | 2 |
| Start Page: | 127 |
| End Page: | 134 |
| Publisher DOI: | 10.1016/j.imlet.2005.10.015 |
| PMID: | 16325270 |
| Abstract: | Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses revealed that autophosphorylation of Thr265 was essential for its full catalytic activity toward an exogenous substrate as well as for cell death induction. Furthermore, leukemia inhibitory factor (LIF) stimulated Thr265 phosphorylation of ZIPK, thereby leading to phosphorylation and activation of signal transducer and activator of transcription (STAT3). Taken together, our findings demonstrate that ZIPK is positively regulated through Thr265 phosphorylation and that this phosphorylation is essential for its function. |
| Relation: | http://www.sciencedirect.com/science/journal/01652478 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/8407 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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