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Identification of pulvomycin as an inhibitor of the futalosine pathway

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Title: Identification of pulvomycin as an inhibitor of the futalosine pathway
Authors: Ogasawara, Yasushi Browse this author →KAKEN DB
Umetsu, Shuhei Browse this author
Inahashi, Yuki Browse this author
Nonaka, Kenichi Browse this author
Dairi, Tohru Browse this author →KAKEN DB
Issue Date: 20-Aug-2021
Publisher: Springer Nature
Journal Title: Journal of antibiotics
Volume: 74
Start Page: 825
End Page: 829
Publisher DOI: 10.1038/s41429-021-00465-8
Abstract: Menaquinone is an essential cofactor in the electron-transfer pathway for bacteria. Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model microorganisms or the futalosine pathway, which we discovered in Streptomyces. Because Helicobacter pylori, which causes stomach cancer, uses the futalosine pathway and most beneficial intestinal bacteria including lactobacilli use the canonical pathway, the futalosine pathway will be a great target to develop antibiotics specific for H. pylori. Here, we searched for such compounds from metabolites produced by actinomycetes and identified pulvomycin from culture broth of Streptomyces sp. K18-0194 as a specific inhibitor of the futalosine pathway.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小笠原 泰志

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