|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >
PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity
| Title: | PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity |
| Authors: | Oziri, Onyinyechukwu Justina Browse this author | | Wang, Yubo Browse this author | | Watanabe, Tomohisa Browse this author | | Uno, Shuya Browse this author | | Maeki, Masatoshi Browse this author | | Tokeshi, Manabu Browse this author →KAKEN DB | | Isono, Takuya Browse this author | | Tajima, Kenji Browse this author →KAKEN DB | | Satoh, Toshifumi Browse this author →KAKEN DB | | Sato, Shin-ichiro Browse this author →KAKEN DB | | Miura, Yutaka Browse this author | | Yamamoto, Takuya Browse this author →KAKEN DB |
| Issue Date: | 21-Feb-2022 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Nanoscale advances |
| Volume: | 2022 |
| Issue: | 4 |
| Start Page: | 532 |
| End Page: | 545 |
| Publisher DOI: | 10.1039/d1na00720c |
| Abstract: | Silver nanoparticles (AgNPs) are practically valuable in biological applications. However, no steady PEGylation has been established, which is essential for internal use in humans or animals. In this study, cyclic PEG (c-PEG) without any chemical inhomogeneity is physisorbed onto AgNPs to successfully PEGylate and drastically enhance the dispersion stability against physiological conditions, white light, and high temperature. In contrast, linear HO-PEG-OH and MeO-PEG-OMe do not confer stability to AgNPs, and HS-PEG-OMe, which is often used for gold nanoparticles, sulfidates the surface to considerably degrade the properties. TEM shows an essentially intact nanostructure of c-PEG-physisorbed AgNPs even after heating at 95 degrees C, while complete disturbance is observed for other AgNPs. Molecular weight- and concentration-dependent stabilization by c-PEG is investigated, and DLS and zeta-potential measurements prove the formation of a c-PEG layer on the surface of AgNPs. Furthermore, c-PEG-physisorbed AgNPs exhibit persistent antimicrobial activity and cytotoxicity. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84175 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
