| Title: | Biosynthesis of Cyclochlorotine : Identification of the Genes Involved in Oxidative Transformations and Intramolecular O,N-Transacylation |
| Authors: | Jiang, Yulu Browse this author |
| Ozaki, Taro Browse this author |
| Liu, Chengwei Browse this author |
| Igarashi, Yuya Browse this author |
| Ye, Ying Browse this author |
| Tang, Shoubin Browse this author |
| Ye, Tao Browse this author |
| Maruyama, Jun-Ichi Browse this author |
| Minami, Atsushi Browse this author |
| Oikawa, Hideaki Browse this author →KAKEN DB |
| Issue Date: | 2-Apr-2021 |
| Publisher: | American Chemical Society |
| Journal Title: | Organic letters |
| Volume: | 23 |
| Issue: | 7 |
| Start Page: | 2616 |
| End Page: | 2620 |
| Publisher DOI: | 10.1021/acs.orglett.1c00525 |
| Abstract: | Mycotoxin cyclochlorotine (1) and structurally related astins are cyclic pentapeptides containing unique nonproteinogenic amino acids, such as beta-phenylalanine, L-allo-threonine, and 3,4-dichloroproline. Herein, we report the biosynthetic pathway for 1, which involves intriguing tailoring processes mediated by DUF3328 proteins, including stereo- and regiospecific chlorination and hydroxylation and intramolecular O,N-transacylation. Our findings demonstrate that DUF3328 proteins, which are known to be involved in oxidative cyclization of fungal ribosomal peptides, have much higher functional diversity than previously expected. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters
, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-IFPMDZCG95XXR2CFZZKZ. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/84440 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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