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Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells

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Title: Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells
Authors: Tsujioka, Takao Browse this author
Sasaki, Daisuke Browse this author
Takeda, Atsuhito Browse this author →KAKEN DB
Harashima, Hideyoshi Browse this author →KAKEN DB
Yamada, Yuma Browse this author →KAKEN DB
Keywords: mitochondria
myocardial cells
mitochondrial delivery
mitochondrial respiratory capacity
Issue Date: 22-Dec-2021
Publisher: MDPI
Journal Title: International Journal of Molecular Sciences
Volume: 23
Issue: 1
Start Page: 112
Publisher DOI: 10.3390/ijms23010112
Abstract: The development of drug delivery systems for use in the treatment of cardiovascular diseases is an area of great interest. We report herein on an evaluation of the therapeutic potential of a myocardial mitochondria-targeting liposome, a multifunctional envelope-type nano device for targeting pancreatic beta cells (beta-MEND) that was previously developed in our laboratory. Resveratrol (RES), a natural polyphenol compound that has a cardioprotective effect, was encapsulated in the beta-MEND (beta-MEND (RES)), and its efficacy was evaluated using rat myocardioblasts (H9c2 cells). The beta-MEND (RES) was readily taken up by H9c2 cells, as verified by fluorescence-activated cell sorter data, and was observed to be colocalized with intracellular mitochondria by confocal laser scanning microscopy. Myocardial mitochondrial function was evaluated by a Seahorse XF Analyzer and the results showed that the beta-MEND (RES) significantly activated cellular maximal respiratory capacity. In addition, the beta-MEND (RES) showed no cellular toxicity for H9c2 cells as evidenced by Premix WST-1 assays. This is the first report of the use of a myocardial mitochondria-targeting liposome encapsulating RES for activating mitochondrial function, which was clearly confirmed based on analyses using a Seahorse XF Analyzer.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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