|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
| Title: | Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis |
| Authors: | Sasaki, Yuto Browse this author | | Saitoh, Kodai Browse this author | | Kagohashi, Kota Browse this author | | Kitai, Yuichi Browse this author →KAKEN DB | | Muromoto, Ryuta Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB | | Kashiwakura, Jun-Ichi Browse this author →KAKEN DB | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | signal-transducing adaptor protein-2 | | autoimmune hepatitis | | interferon-γ (IFN-γ) | | Fas ligand (FasL) | | caspase-3 |
| Issue Date: | 1-Dec-2021 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | Biological & pharmaceutical bulletin |
| Volume: | 44 |
| Issue: | 12 |
| Start Page: | 1898 |
| End Page: | 1901 |
| Publisher DOI: | 10.1248/bpb.b21-00595 |
| Abstract: | Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis. After intravenous injection of concanavalin A (ConA), STAP-2 knock out (KO) mice showed more severe liver necrosis along with substantial lymphocyte infiltration compared to wild type (WT) mice. Serum alanine aminotransferase levels were significantly higher in ConA-injected STAP-2 KO mice than in WT mice. Levels of interferon-gamma (IFN-gamma), an important factor for liver necrosis, were also significantly increased in sera of STAP-2 KO mice compared to WT mice after ConA injection. Statistically significant upregulation of Fas ligand (FasL) expression was observed in the livers of ConA-injected STAP-2 KO mice compared to WT mice. In accordance with these results, apoptotic signals were facilitated in STAP-2 KO mice compared to WT mice after ConA injection. Correctively, these results suggest that STAP-2 is involved in the pathogenesis of autoimmune hepatitis by regulating the expression of FasL and the production of IFN-gamma. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84699 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
