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One-Shot Intrablock Cross-Linking of Linear Diblock Copolymer to Realize Janus-Shaped Single-Chain Nanoparticles

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Title: One-Shot Intrablock Cross-Linking of Linear Diblock Copolymer to Realize Janus-Shaped Single-Chain Nanoparticles
Authors: Watanabe, Kodai Browse this author
Kaizawa, Noya Browse this author
Ree, Brian J. Browse this author
Yamamoto, Takuya Browse this author →KAKEN DB
Tajima, Kenji Browse this author →KAKEN DB
Isono, Takuya Browse this author
Satoh, Toshifumi Browse this author →KAKEN DB
Keywords: block copolymers
intramolecular cross-linking
Janus-shaped single-chain nanoparticles
microphase separation
Issue Date: 9-Aug-2021
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie-international edition
Volume: 60
Issue: 33
Start Page: 18122
End Page: 18128
Publisher DOI: 10.1002/anie.202103969
Abstract: Developing an efficient and versatile process to transform a single linear polymer chain into a shape-defined nanoobject is a major challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in a synthetic polymer system. In this study, we performed one-shot intrablock crosslinking of linear block copolymers (BCPs) to realize single-chain nanoparticles (SCNPs) with two chemically compartmentalized domains (i.e., Janus-shaped SCNPs). Detailed structural characterizations of the Janus-shaped SCNP composed of polystyrene-block-poly(glycolic acid) revealed its compactly folded conformation and compartmentalized block localization, similar to the self-folded tertiary structures of natural proteins. Versatility of the one-shot intrablock crosslinking was demonstrated using several different BCP precursors. We further discovered the excellent self-assembling behavior of the Janus-shaped SCNP to produce miniscule microphase-separated structures, representing the significant potential of the presented compartmentalization protocol, for developing biomimetic synthetic-systems, as well as for industrial nanofabrication applications.
Rights: This is the peer reviewed version of the following article: K. Watanabe, N. Kaizawa, B. J. Ree, T. Yamamoto, K. Tajima, T. Isono, T. Satoh, Angew. Chem. Int. Ed. 2021, 60, 18122. , which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 敏文

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