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Hokkaido University Collection of Scholarly and Academic Papers >
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One-Shot Intrablock Cross-Linking of Linear Diblock Copolymer to Realize Janus-Shaped Single-Chain Nanoparticles
| Title: | One-Shot Intrablock Cross-Linking of Linear Diblock Copolymer to Realize Janus-Shaped Single-Chain Nanoparticles |
| Authors: | Watanabe, Kodai Browse this author | | Kaizawa, Noya Browse this author | | Ree, Brian J. Browse this author | | Yamamoto, Takuya Browse this author →KAKEN DB | | Tajima, Kenji Browse this author →KAKEN DB | | Isono, Takuya Browse this author | | Satoh, Toshifumi Browse this author →KAKEN DB |
| Keywords: | block copolymers | | compartmentalization | | intramolecular cross-linking | | Janus-shaped single-chain nanoparticles | | microphase separation |
| Issue Date: | 9-Aug-2021 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Angewandte chemie-international edition |
| Volume: | 60 |
| Issue: | 33 |
| Start Page: | 18122 |
| End Page: | 18128 |
| Publisher DOI: | 10.1002/anie.202103969 |
| Abstract: | Developing an efficient and versatile process to transform a single linear polymer chain into a shape-defined nanoobject is a major challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in a synthetic polymer system. In this study, we performed one-shot intrablock crosslinking of linear block copolymers (BCPs) to realize single-chain nanoparticles (SCNPs) with two chemically compartmentalized domains (i.e., Janus-shaped SCNPs). Detailed structural characterizations of the Janus-shaped SCNP composed of polystyrene-block-poly(glycolic acid) revealed its compactly folded conformation and compartmentalized block localization, similar to the self-folded tertiary structures of natural proteins. Versatility of the one-shot intrablock crosslinking was demonstrated using several different BCP precursors. We further discovered the excellent self-assembling behavior of the Janus-shaped SCNP to produce miniscule microphase-separated structures, representing the significant potential of the presented compartmentalization protocol, for developing biomimetic synthetic-systems, as well as for industrial nanofabrication applications. |
| Rights: | This is the peer reviewed version of the following article: K. Watanabe, N. Kaizawa, B. J. Ree, T. Yamamoto, K. Tajima, T. Isono, T. Satoh, Angew. Chem. Int. Ed. 2021, 60, 18122. , which has been published in final form at https://doi.org/10.1002/anie.202103969. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86468 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 敏文
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