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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Saponins are responsible for the anti-obesogenic activity of Acacia concinna
| Title: | Saponins are responsible for the anti-obesogenic activity of Acacia concinna |
| Authors: | Zhuoyue, Zhao Browse this author | | Ruangaram, Wijitrapha Browse this author | | Kato, Eisuke Browse this author →KAKEN DB |
| Keywords: | Acacia concinna | | Saponin | | Obesity | | Pancreatic lipase | | Lipolysis |
| Issue Date: | Sep-2021 |
| Publisher: | Springer |
| Journal Title: | Journal of natural medicines |
| Volume: | 75 |
| Start Page: | 1005 |
| End Page: | 1013 |
| Publisher DOI: | 10.1007/s11418-021-01530-0 |
| Abstract: | Acacia concinna (Willd.) DC. is a medicinal plant sourced mainly from Southeast Asia. The pods of Acacia concinna (A. concinna) are a potential candidate to treat or prevent obesity; however, these medicinal attributes have not been examined in detail. In this study, the anti-obesogenic compounds in A. concinna pods were investigated. Chromatographic separation of the pod extract guided by pancreatic lipase inhibitory activity led to the isolation of saponins. Decomposition analysis of the saponins revealed their chemical composition to be acacic acid, monoterpenes, and five types of sugars (glucose, xylose, rhamnose, quinovose, arabinose). The predicted structures of the saponins from decomposition analysis were confirmed by LC-MS analysis, showing that these saponins are mixture of various derivatives of monoterpenes and sugar units. These saponins inhibited pancreatic lipase activity strongly with an IC50 of 7.9 mu g/mL, and reduced lipid accumulation in 3T3-L1 adipocytes at 6.3 mu g/mL. The saponins also enhanced lipolysis of 3T3-L1 adipocytes at 3.1 or 6.3 mu g/mL by mediating the activity of protein kinase A and extracellular signal-regulated kinase pathways, suggesting that this mechanism is partly responsible for the observed reduction of lipid content in adipocytes. The results underline A. concinna as a potential source of the anti-obesogenic candidates for the future treatment and prevention of obesity. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Journal of natural medicines. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11418-021-01530-0 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86646 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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