HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >

Saponins are responsible for the anti-obesogenic activity of Acacia concinna

Files in This Item:
Eikato_JNatProd_2021.pdf337.24 kBPDFView/Open
Eikato_JNatProd_2021_Supplementary material.pdf6.2 MBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Saponins are responsible for the anti-obesogenic activity of Acacia concinna
Authors: Zhuoyue, Zhao Browse this author
Ruangaram, Wijitrapha Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Keywords: Acacia concinna
Pancreatic lipase
Issue Date: Sep-2021
Publisher: Springer
Journal Title: Journal of natural medicines
Volume: 75
Start Page: 1005
End Page: 1013
Publisher DOI: 10.1007/s11418-021-01530-0
Abstract: Acacia concinna (Willd.) DC. is a medicinal plant sourced mainly from Southeast Asia. The pods of Acacia concinna (A. concinna) are a potential candidate to treat or prevent obesity; however, these medicinal attributes have not been examined in detail. In this study, the anti-obesogenic compounds in A. concinna pods were investigated. Chromatographic separation of the pod extract guided by pancreatic lipase inhibitory activity led to the isolation of saponins. Decomposition analysis of the saponins revealed their chemical composition to be acacic acid, monoterpenes, and five types of sugars (glucose, xylose, rhamnose, quinovose, arabinose). The predicted structures of the saponins from decomposition analysis were confirmed by LC-MS analysis, showing that these saponins are mixture of various derivatives of monoterpenes and sugar units. These saponins inhibited pancreatic lipase activity strongly with an IC50 of 7.9 mu g/mL, and reduced lipid accumulation in 3T3-L1 adipocytes at 6.3 mu g/mL. The saponins also enhanced lipolysis of 3T3-L1 adipocytes at 3.1 or 6.3 mu g/mL by mediating the activity of protein kinase A and extracellular signal-regulated kinase pathways, suggesting that this mechanism is partly responsible for the observed reduction of lipid content in adipocytes. The results underline A. concinna as a potential source of the anti-obesogenic candidates for the future treatment and prevention of obesity.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Journal of natural medicines. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University