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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
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Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2
| Title: | Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2 |
| Authors: | Takeda, Ryo Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB | | Sasaki, Michihito Browse this author →KAKEN DB | | Orba, Yasuko Browse this author →KAKEN DB | | Maishi, Nako Browse this author →KAKEN DB | | Tsumita, Takuya Browse this author | | Ushijima, Natsumi Browse this author →KAKEN DB | | Hida, Yasuhiro Browse this author →KAKEN DB | | Sano, Hidehiko Browse this author →KAKEN DB | | Kitagawa, Yoshimasa Browse this author →KAKEN DB | | Hida, Kyoko Browse this author →KAKEN DB |
| Issue Date: | 18-Aug-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 14050 |
| Publisher DOI: | 10.1038/s41598-022-18367-6 |
| PMID: | 35982118 |
| Abstract: | Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 mu g/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86766 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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