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Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

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Title: Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2
Authors: Takeda, Ryo Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Sasaki, Michihito Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Maishi, Nako Browse this author →KAKEN DB
Tsumita, Takuya Browse this author
Ushijima, Natsumi Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author →KAKEN DB
Sano, Hidehiko Browse this author →KAKEN DB
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Hida, Kyoko Browse this author →KAKEN DB
Issue Date: 18-Aug-2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Issue: 1
Start Page: 14050
Publisher DOI: 10.1038/s41598-022-18367-6
PMID: 35982118
Abstract: Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 mu g/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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