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Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities
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| Title: | Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities |
| Authors: | Hayashi, Naoki Browse this author | | Kouguchi, Hirokazu Browse this author | | Imasato, Yuhei Browse this author | | Irie, Takao Browse this author | | Yagi, Kinpei Browse this author →KAKEN DB | | Nonaka, Nariaki Browse this author →KAKEN DB | | Nakao, Ryo Browse this author →KAKEN DB |
| Keywords: | Echinococcus multilocularis | | Migration dynamics | | Oncospheres | | Primary alveolar echinococcosis | | qPCR |
| Issue Date: | 1-Oct-2021 |
| Publisher: | Elsevier |
| Journal Title: | International journal for parasitology |
| Volume: | 51 |
| Issue: | 11 |
| Start Page: | 893 |
| End Page: | 898 |
| Publisher DOI: | 10.1016/j.ijpara.2021.04.001 |
| Abstract: | The early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared the parasite burden in the intestine, liver and faeces of DBA/2 and C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that the parasites invaded mainly from the middle segments of the small intestine and completed migration to the liver within 24 h p.i. C57BL/6 mice had lower parasite DNA burdens in the intestine and liver but higher in the faeces than DBA/2 mice, suggesting that parasite invasion of the intestine may be a critical stage regulating susceptibility to E. multilocularis infection in mice. (c) 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved. |
| Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86895 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 中尾 亮
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