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Performance Status 不良群におけるナルデメジンの有効性の検証

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Title: Performance Status 不良群におけるナルデメジンの有効性の検証
Other Titles: Efficacy Survey of Naldemedine in the Poor-performance Status Group
Authors: Kato, Shintaro Browse this author
Saito, Yoshitaka Browse this author →KAKEN DB
Onoda, Hiroko Browse this author
Kumai, Masayoshi Browse this author
Imai, Shungo Browse this author →KAKEN DB
Tsuruga, Kenkichi Browse this author →KAKEN DB
Takekuma, Yoh Browse this author →KAKEN DB
Sugawara, Mitsuru Browse this author →KAKEN DB
Keywords: opioid-induced constipation
medical narcotic
pharmaceutical care
supportive care
Issue Date: 1-Jul-2022
Publisher: The Pharmaceutical Society of Japan
Journal Title: Yakugaku zasshi
Journal Title(alt): 薬学雑誌
Volume: 142
Issue: 7
Start Page: 755
End Page: 760
Publisher DOI: 10.1248/yakushi.22-00005
Abstract: Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation. However, patients in phase III trials are limited to those with good performance status (PS). Cancer patients may have inferior PS owing to progression of symptoms and adverse events from chemotherapy. Therefore, it is important to survey the efficacy of Nal in patients with poor PS. This study aimed to evaluate Nal efficacy in patients with poor PS. We retrospectively investigated patients from July 2017 to June 2019 and compared Nal efficacy between patients with good and poor PS. The efficacy of Nal was evaluated using changes in the number of spontaneous bowel movements 7 days before and after the introduction of Nal with reference to previous reports. Multivariate analysis was performed to reveal whether poor PS affects Nal efficacy. In total, 141 patients at the Hokkaido University Hospital were analyzed. The effective rate of Nal from day 1 to day 7 of administration was 71.7% and 71.4% in the patients with good and poor PS, respectively, that from day 1 to day 2 of administration was 61.1% and 57.1%, respectively, and that from day 3 to day 7 of administration was 60.2% and 71.4%, respectively, suggesting an absence of significant differences. Furthermore, results of multivariate analysis showed that best supportive care'' and body weight (55 kg and above)'' reduced Nal efficacy. In conclusion, Nal showed similar effectiveness in patients with poor PS as that in those with good PS.
Rights: Copyright 2022 The Pharmaceutical Society of Japan
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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