Title: | Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation |
Authors: | Kashiwakura, Jun-ichi Browse this author →KAKEN DB |
Koizumi, Nao Browse this author |
Saitoh, Kodai Browse this author |
Kagohashi, Kota Browse this author |
Sasaki, Yuto Browse this author |
Kobayashi, Fuki Browse this author |
Kawahara, Shoya Browse this author |
Yamauchi, Yukie Browse this author |
Kitai, Yuichi Browse this author →KAKEN DB |
Muromoto, Ryuta Browse this author →KAKEN DB |
Oritani, Kenji Browse this author →KAKEN DB |
Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | Mast cells |
IL-33 |
Signal-transducing adaptor molecule-2 |
ST2 |
NF-kappa B |
Issue Date: | 1-Oct-2021 |
Publisher: | Elsevier |
Journal Title: | Biochemical and biophysical research communications |
Volume: | 572 |
Start Page: | 80 |
End Page: | 85 |
Publisher DOI: | 10.1016/j.bbrc.2021.07.098 |
Abstract: | Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of Fc epsilon RI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet. In the present study, we mainly investigated functional roles of STAP-2 in IL-33-induced mast cell activation. In STAP-2-deficient, but not STAP-1-deficient, mast cells, IL-33-induced IL-6 and TNF-alpha production was significantly decreased compared with that of wild-type mast cells. In addition, STAP-2-deficiency greatly reduced TLR4-mediated mast cell activation and cytokine production. For the mechanisms, STAP-2 directly binds to IKK alpha after IL-33 stimulation, leading to elevated NF-kappa B activity. In conclusion, STAP-2, but not STAP-1, participates in IL-33-induced mast cells activation. |
Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/87011 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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