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Effect of Organic Solvents on a Production of PLGA-Based Drug- Loaded Nanoparticles Using a Microfluidic Device
| Title: | Effect of Organic Solvents on a Production of PLGA-Based Drug- Loaded Nanoparticles Using a Microfluidic Device |
| Authors: | Bao, Yi Browse this author | | Maeki, Masatoshi Browse this author | | Ishida, Akihiko Browse this author →KAKEN DB | | Tani, Hirofumi Browse this author →KAKEN DB | | Tokeshi, Manabu Browse this author →KAKEN DB |
| Keywords: | Amorphous materials | | Copolymers | | Encapsulation | | Microfluidic devices | | Solvents |
| Issue Date: | 6-Sep-2022 |
| Publisher: | American Chemical Society |
| Journal Title: | ACS Omega |
| Volume: | 7 |
| Issue: | 37 |
| Start Page: | 33079 |
| End Page: | 33086 |
| Publisher DOI: | 10.1021/acsomega.2c03137 |
| Abstract: | The translation of nanoparticles (NPs) from laboratory to clinical settings is limited, which is not ideal. One of the reasons for this is that we currently have limited ability to precisely regulate various physicochemical parameters of nanoparticles. This has made it difficult to rapidly perform targeted screening of drug preparation conditions. In this study, we attempted to broaden the range of preparation conditions for particle size-modulated poly(lactic-co-glycolic-acid) (PLGA) NP to enhance their applicability for drug delivery systems (DDS). This was done using a variety of organic solvents and a glass-based microfluidic device. Furthermore, we compared the PDMS-based microfluidic device to the glass-based microfluidic device in terms of the possibility of a wider range of preparation conditions, especially the effect of different solvents on the size of the PLGA NPs. PLGA NPs with different sizes (sub-200 nm) were successfully prepared, and three different types of taxanes were employed for encapsulation. The drug-loaded NPs showed size-dependent cytotoxicity in cellular assays, regardless of the taxane drug used. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87275 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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