|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Development and validation of a prediction model based on the organ-based metabolic tumor volume on FDG-PET in patients with differentiated thyroid carcinoma
| Title: | Development and validation of a prediction model based on the organ-based metabolic tumor volume on FDG-PET in patients with differentiated thyroid carcinoma |
| Authors: | Uchiyama, Yuko Browse this author | | Hirata, Kenji Browse this author →KAKEN DB | | Watanabe, Shiro Browse this author | | Okamoto, Shozo Browse this author | | Shiga, Tohru Browse this author | | Okada, Kazufumi Browse this author | | Ito, Yoichi M. Browse this author | | Kudo, Kohsuke Browse this author →KAKEN DB |
| Keywords: | Differentiated thyroid carcinoma | | Metabolic tumor volume | | Organ-based measurement | | FDG-PET |
| Issue Date: | 1-Nov-2021 |
| Publisher: | Springer |
| Journal Title: | Annals of nuclear medicine |
| Volume: | 35 |
| Issue: | 11 |
| Start Page: | 1223 |
| End Page: | 1231 |
| Publisher DOI: | 10.1007/s12149-021-01664-x |
| Abstract: | Background Although patients with differentiated thyroid cancer (DTC) generally have a good prognosis, patients with a large metabolic tumor volume (MTV) on FDG-PET may experience poor clinical courses. We measured organ-based MTVs and tested its prognostic performance in comparison to conventional MTV (cMTV). Methods We retrospectively analyzed the cases of 280 patients who received their first I-131 therapy in 2003-2014 at our hospital and showed an FDG-avid metastatic lesion. We randomly divided the patients into training (n = 190) and validation (n = 90) datasets. We classified the MTVs as MTVneck-node, MTVdistant-node, MTVlung, MTVbone, and MTVother-organs and tested with/without dichotomization vis-a-vis overall survival (OS). Based on the estimated weighting coefficients of the organ-based MTVs, we propose a new index: the adjusted whole-body MTV (aMTV). Using the validation dataset, we compared the aMTV with cMTV for predicting OS. Results In a univariate analysis, MTVdistant-node and MTVother-organs were more strongly correlated with the OS than the dichotomized forms, whereas the dichotomized forms of MTVneck-node, MTVlung, and MTVbone were more strongly correlated with OS than the continuous variables. The aMTV was thus expressed as 0.69 x dic(MTVneck-node) + 0.02 x MTVdistant-node + 1.05 x dic(MTVlung) + 1.58 x dic(MTVbone) + 0.01 x MTVother-organs, where dic(x) represents 0 or 1 based on the optimized cut-off. In the model evaluation using the validation group, aMTV was a significant predictor of OS with a higher c-index (0.7676) than cMTV (0.7218). Conclusion In DTC patients with FDG-avid metastasis before I-131 therapy, all organ-based MTVs were significant predictors of prognosis. As the aMTV outperformed the cMTV for predicting prognoses, we recommend measuring the MTV on an organ basis. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Annals of nuclear medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12149-021-01664-x. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87316 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 平田 健司
|
