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New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents
| Title: | New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents |
| Authors: | Haedar, Jabal Rahmat Browse this author | | Uria, Agustinus Robert Browse this author →KAKEN DB | | Lallo, Subehan Browse this author | | Dibwe, Dya Fita Browse this author | | Wakimoto, Toshiyuki Browse this author →KAKEN DB |
| Keywords: | marine sponge | | Theonella swinhoei | | depsipeptide | | preferential cytotoxicity | | theonellapeptolide-type compounds | | anti-pancreatic cancer agents | | anti-austerity agents |
| Issue Date: | 25-Oct-2022 |
| Publisher: | MDPI |
| Journal Title: | Marine drugs |
| Volume: | 20 |
| Issue: | 11 |
| Start Page: | 661 |
| Publisher DOI: | 10.3390/md20110661 |
| Abstract: | We reported three new members of the theonellapeptolide family from theonellapeptolide II series, namely theonellapeptolides IIb (1), IIa (2), IIc (3), and three known members-IId (4), IIe (5), and Id (6)-from Kodingarengan marine sponge Theonella swinhoei collected in Makassar, Indonesia. The structures of tridecadepsipeptides 1-3, including the absolute configurations of their amino acids, were determined by the integrated NMR and tandem MS analyses followed by Marfey's analysis. To the best of our knowledge, 1 and 2 are the first theonellapeptolide-type compounds to have a valine residue with (D) configuration at residue position 6. The isolated theonellapeptolide-type compounds 1-6 showed selective cytotoxic activity against human pancreatic MIA PaCa-2 cancer cells in a nutrient-deprived medium. Among them, the most potent preferential cytotoxicity was observed in new theonellapeptolide IIc (3) and known IId (4), IIe (5), and Id (6). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87535 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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