Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

Sasaki, Akihiro; Kato, Tatsuya; Ujiie, Hideki; Wakasa, Satoru; Otake, Setsuyuki; Kikuchi, Keisuke; Ohno, Koichi

doi:10.5761/atcs.cr.21-00052


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Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/87640

Title:	Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery
Authors:	Sasaki, Akihiro Browse this author
	Kato, Tatsuya Browse this author
	Ujiie, Hideki Browse this author
	Wakasa, Satoru Browse this author
	Otake, Setsuyuki Browse this author
	Kikuchi, Keisuke Browse this author
	Ohno, Koichi Browse this author
Keywords:	stiff-person syndrome
	paraneoplastic stiff-person syndrome
	thymoma
	anti-acetylcholine receptor antibody
	myasthenia gravis
Issue Date:	Dec-2022
Publisher:	The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
Journal Title:	Annals of Thoracic and Cardiovascular Surgery
Volume:	28
Issue:	6
Start Page:	448
End Page:	452
Publisher DOI:	10.5761/atcs.cr.21-00052
Abstract:	Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder.Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately5% of all SPS cases. We present a rare case of thymoma accompanied by SPSsuccessfully treated using surgery.Presentation of Case: A 26-year-old woman presented with lower limbs convulsions andgait disturbance and complained of leg pain. Cerebrospinal fluid and blood test resultsshowed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computedtomography showed anterior mediastinal tumor suggestive of a thymoma. She underwentextended thymectomy, and her symptoms gradually improved after surgery. No evidenceof recurrent thymoma and SPS has been observed over 44 months.Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.
Rights:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Type:	article
URI:	http://hdl.handle.net/2115/87640
Appears in Collections:	北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 氏家秀樹

OAI-PMH ( junii2 , jpcoar_1.0 )

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