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Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

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Title: Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery
Authors: Sasaki, Akihiro Browse this author
Kato, Tatsuya Browse this author
Ujiie, Hideki Browse this author
Wakasa, Satoru Browse this author
Otake, Setsuyuki Browse this author
Kikuchi, Keisuke Browse this author
Ohno, Koichi Browse this author
Keywords: stiff-person syndrome
paraneoplastic stiff-person syndrome
anti-acetylcholine receptor antibody
myasthenia gravis
Issue Date: Dec-2022
Publisher: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
Journal Title: Annals of Thoracic and Cardiovascular Surgery
Volume: 28
Issue: 6
Start Page: 448
End Page: 452
Publisher DOI: 10.5761/
Abstract: Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder.Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately5% of all SPS cases. We present a rare case of thymoma accompanied by SPSsuccessfully treated using surgery.Presentation of Case: A 26-year-old woman presented with lower limbs convulsions andgait disturbance and complained of leg pain. Cerebrospinal fluid and blood test resultsshowed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computedtomography showed anterior mediastinal tumor suggestive of a thymoma. She underwentextended thymectomy, and her symptoms gradually improved after surgery. No evidenceof recurrent thymoma and SPS has been observed over 44 months.Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 氏家 秀樹

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