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Unimodal and Well-Defined Nanomicelles Assembled by Topology-Controlled Bicyclic Block Copolymers

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Title: Unimodal and Well-Defined Nanomicelles Assembled by Topology-Controlled Bicyclic Block Copolymers
Authors: Ree, Brian J. Browse this author
Satoh, Yusuke Browse this author
Jin, Kyeong Sik Browse this author
Isono, Takuya Browse this author
Satoh, Toshifumi Browse this author →KAKEN DB
Keywords: topological bicyclic amphiphiles
synchrotro n X-ray scattering
ellipsoidal core-shell micelle
unimodal size distribution
radial density profile
Issue Date: 14-Jan-2022
Publisher: American Chemical Society
Journal Title: Macromolecules
Volume: 55
Issue: 3
Start Page: 862
End Page: 872
Publisher DOI: 10.1021/acs.macromol.1c01916
Abstract: This study provides first insights into the micellization behavior and micellar morphologies of bicyclic amphiphiles in four different topologies: bicy-BCP-A, bicy-BCP-B, bicy-BCP-C, and bicy-BCP-D, consisting of poly(n-decyl glycidyl ether) and poly(2-(2-(2-methoxyethoxy)ethoxy)ethyl glycidyl ether) blocks in equivalent molar fractions. Quantitative synchrotron X-ray scattering analysis reveals that all bicyclic amphiphiles self-assemble into unimodal nanomicelles consisting of core, dense corona, and soft corona structural components. The micelles also demonstrate substantial size reductions (56.7-70.7%) compared to micelles of their linear counterpart (l-BCP). The critical micelle concentration, stability, and structural parameters (shape, size, and others) of nanomicelles are differentiated by controlling the bicyclic topology types. bicy-BCP-A, -B, and -C form oblate ellipsoidal micelles, whereas bicy-BCP-D and l-BCP assemble into prolate ellipsoidal micelles. The size is found to be in the following order: bicy-BCP-D < bicy-BCP-C < bicy-BCP-B < bicy-BCP-A << l-BCP. Furthermore, the structural stability is in the following order: l-BCP < bicyBCP-D << bicy-BCP-B < bicy-BCP-C < bicy-BCP-A. These results indicate that the topology-controlled bicyclic block copolymers can be used as a desirable platform for developing high-performance functional core-shell nanoparticles for advanced applications in various fields, including smart drug delivery, biomedical imaging, cosmetics, advanced coating appliances, and molecular electronics.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Macromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 敏文

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