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Current understanding of the role of tyrosine kinase 2 signaling in immune responses
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| Title: | Current understanding of the role of tyrosine kinase 2 signaling in immune responses |
| Authors: | Muromoto, Ryuta Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | Tyrosine kinase 2 | | Cytokines | | Signal transduction | | Immune system | | Inflammation |
| Issue Date: | 27-Jan-2022 |
| Publisher: | Baishideng Publishing Group |
| Journal Title: | World Journal of Biological Chemistry |
| Volume: | 13 |
| Issue: | 1 |
| Start Page: | 1 |
| End Page: | 14 |
| Publisher DOI: | 10.4331/wjbc.v13.i1.1 |
| Abstract: | Immune system is a complex network that clears pathogens, toxic substrates, and
cancer cells. Distinguishing self-antigens from non-self-antigens is critical for the
immune cell-mediated response against foreign antigens. The innate immune
system elicits an early-phase response to various stimuli, whereas the adaptive
immune response is tailored to previously encountered antigens. During immune
responses, B cells differentiate into antibody-secreting cells, while naïve T cells
differentiate into functionally specific effector cells [T helper 1 (Th1), Th2, Th17,
and regulatory T cells]. However, enhanced or prolonged immune responses can
result in autoimmune disorders, which are characterized by lymphocytemediated
immune responses against self-antigens. Signal transduction of
cytokines, which regulate the inflammatory cascades, is dependent on the
members of the Janus family of protein kinases. Tyrosine kinase 2 (Tyk2) is
associated with receptor subunits of immune-related cytokines, such as type I
interferon, interleukin (IL)-6, IL-10, IL-12, and IL-23. Clinical studies on the
therapeutic effects and the underlying mechanisms of Tyk2 inhibitors in
autoimmune or chronic inflammatory diseases are currently ongoing. This review
summarizes the findings of studies examining the role of Tyk2 in immune and/or
inflammatory responses using Tyk2-deficient cells and mice. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87686 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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