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Signal transducer and activator of transcription 3 regulation by novel binding partners.

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Title: Signal transducer and activator of transcription 3 regulation by novel binding partners.
Authors: Matsuda, Tadashi Browse this author →KAKEN DB
Muromoto, Ryuta Browse this author →KAKEN DB
Sekine, Yuichi Browse this author →KAKEN DB
Togi, Sumihito Browse this author
Kitai, Yuichi Browse this author →KAKEN DB
Kon, Shigeyuki Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Keywords: Janus kinase/signal transducer and activator of transcription
Signal transduction
Signal transducer and activator of transcription 3
Zipper-interacting protein kinase
Krüppel-associated box-associated protein 1
PDZ and LIM domain 2
Signal transducing adaptor protein-2
Nuclear factor-κB
Issue Date: 26-Nov-2015
Publisher: Baishideng Publishing Group
Journal Title: World journal of biological chemistry
Volume: 6
Issue: 4
Start Page: 324
End Page: 332
Publisher DOI: 10.4331/wjbc.v6.i4.324
PMID: 26629315
Abstract: Signal transducers and activators of transcription (STATs) mediate essential signals for various biological processes, including immune responses, hematopoiesis, and neurogenesis. STAT3, for example, is involved in the pathogenesis of various human diseases, including cancers, autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2, in the regulation of STAT3-mediated signaling.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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