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Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers : Tumorigenesis and Immunosurveillance
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers : Tumorigenesis and Immunosurveillance |
| Authors: | Hashimoto, Shigeru Browse this author →KAKEN DB | | Hashimoto, Ari Browse this author →KAKEN DB | | Muromoto, Ryuta Browse this author →KAKEN DB | | Kitai, Yuichi Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | STAT3 | | tumorigenesis | | immune evasion | | STAP-2 | | ARID5A |
| Issue Date: | 22-Aug-2022 |
| Publisher: | MDPI |
| Journal Title: | Cells |
| Volume: | 11 |
| Issue: | 16 |
| Start Page: | 2618 |
| Publisher DOI: | 10.3390/cells11162618 |
| Abstract: | Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains unclear
whether a collapse of the balance between the antitumor immune response via the immunological
surveillance system and protumor immunity due to cancer-related inflammation is responsible for
cancer malignancy. The majority of inflammatory signals affect tumorigenesis by activating signal
transducer and activation of transcription 3 (STAT3) and nuclear factor-κB. Persistent STAT3 activation
in malignant cancer cells mediates extremely widespread functions, including cell growth, survival,
angiogenesis, and invasion and contributes to an increase in inflammation-associated tumorigenesis.
In addition, intracellular STAT3 activation in immune cells causes suppressive effects on antitumor
immunity and leads to the differentiation and mobilization of immature myeloid-derived cells and
tumor-associated macrophages. In many cancer types, STAT3 does not directly rely on its activation by
oncogenic mutations but has important oncogenic and malignant transformation-associated functions
in both cancer and stromal cells in the tumor microenvironment (TME). We have reported a series of
studies aiming towards understanding the molecular mechanisms underlying the proliferation of
various types of tumors involving signal-transducing adaptor protein-2 as an adaptor molecule that
modulates STAT3 activity, and we recently found that AT-rich interactive domain-containing protein
5a functions as an mRNA stabilizer that orchestrates an immunosuppressive TME in malignant
mesenchymal tumors. In this review, we summarize recent advances in our understanding of
the functional role of STAT3 in tumor progression and introduce novel molecular mechanisms of
cancer development and malignant transformation involving STAT3 activation that we have identified
to date. Finally, we discuss potential therapeutic strategies for cancer that target the signaling pathway
to augment STAT3 activity. |
| Rights: | http://creativecommons.org/licenses/by/4.0 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87702 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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