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Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior
| Title: | Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior |
| Authors: | Arakaki, Saya Browse this author | | Minami, Masabumi Browse this author →KAKEN DB |
| Keywords: | bed nucleus of the stria terminalis | | nicotine withdrawal | | noradrenaline |
| Issue Date: | 19-Apr-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Neuropsychopharmacology Reports |
| Volume: | 42 |
| Issue: | 2 |
| Start Page: | 233 |
| End Page: | 237 |
| Publisher DOI: | 10.1002/npr2.12252 |
| Abstract: | Aim: Cessation of smoking induces nicotine withdrawal symptoms such as anxiety, depression, and dysphoria, which could lead to smoking relapse. In the present study, we examined the role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis (vBNST) on nicotine withdrawal-induced aversive behavior. Methods: Nicotine dependence in rats was established by subcutaneous implantation with a nicotine-filled osmotic minipump on day 1. Nicotine withdrawal was precipi-tated by administration of the nicotine receptor antagonist, mecamylamine (3.0 mg/kg, s.c.), on day 15. Nicotine withdrawal-induced intra-vBNST noradrenaline release and aversive behavior were examined by in vivo microdialysis and a conditioned place aversion (CPA) test, respectively. Results: Intra-vBNST noradrenaline release was significantly increased during nico-tine withdrawal. Nicotine withdrawal induced aversive behavior, which was attenu-ated by intra-vBNST injection of the β- adrenoceptor antagonist, timolol. Conclusions: These results suggest that enhanced noradrenergic transmission via β- adrenoceptors in the vBNST plays a crucial role in nicotine withdrawal-induced aver-sive behavior. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87712 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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