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Whole-genome sequencing analysis of wild house mice (Mus musculus) captured in Madagascar
Title: | Whole-genome sequencing analysis of wild house mice (Mus musculus) captured in Madagascar |
Authors: | Fujiwara, Kazumichi Browse this author | Ranorosoa, Marie C. Browse this author | Ohdachi, Satoshi D. Browse this author →KAKEN DB | Arai, Satoru Browse this author →KAKEN DB | Sakuma, Yuki Browse this author | Suzuki, Hitoshi Browse this author →KAKEN DB | Osada, Naoki Browse this author →KAKEN DB |
Keywords: | house mouse | Mus musculus | Madagascar | whole-genome sequence | population genetics |
Issue Date: | 1-Aug-2022 |
Publisher: | 日本遺伝学会(The Genetics Society of Japan) |
Journal Title: | Genes & Genetic Systems |
Volume: | 97 |
Issue: | 4 |
Start Page: | 193 |
End Page: | 207 |
Publisher DOI: | 10.1266/ggs.22-00090 |
Abstract: | In Madagascar, the house mouse (Mus musculus) is widely believed to have colonized with human activities and is now one of the most abundant rodents on the island. However, its genetic background at the genomic level remains unclear, and clarifying this would help us to infer the timing of introduction and route of migration. In this study, we determined the whole-genome sequences of five Madagascar house mice captured from an inland location in Madagascar. We examined the genetic background of samples by analyzing the mitochondrial and autosomal genomes. We confirmed that the mitochondrial genome lineages of collected samples formed a single clade placed at one of the most basal positions in the Mus musculus species. Autosomal genomic sequences revealed that these samples are most closely related to the subspecies M. m. castaneus (CAS), but also contain a genetic component of the subspecies M. m. domesticus (DOM). The signature of a strong population bottleneck 1,000-3,000 years ago was observed in both mitochondrial and autosomal genomic data. In a comparison with global samples of M. musculus, the Madagascar samples showed strong genetic affinity to many CAS samples across a wide range of Indian Ocean coastal and insular regions, with divergence time estimated as around 4,000 years ago. These findings support the proposition that the ancestors of these animals started to colonize the island with human agricultural activity and experienced a complex history during their establishment. |
Type: | article |
URI: | http://hdl.handle.net/2115/88102 |
Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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