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Counterpropagating Gradients of Antibacterial and Antifouling Polymer Brushes

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Title: Counterpropagating Gradients of Antibacterial and Antifouling Polymer Brushes
Authors: Ko, Yeongun Browse this author
Truong, Vi Khanh Browse this author
Woo, Sun Young Browse this author
Dickey, Michael D. Browse this author
Hsiao, Lilian Browse this author
Genzer, Jan Browse this author
Keywords: Antifouling
Chemical reactions
Issue Date: 10-Jan-2022
Publisher: American Chemical Society
Journal Title: Biomacromolecules
Volume: 23
Issue: 1
Start Page: 424
End Page: 430
Publisher DOI: 10.1021/acs.biomac.1c01386
Abstract: We report on the formation of counterpropagating density gradients in poly([2-dimethylaminoethyl] methacrylate) (PDMAEMA) brushes featuring spatially varying quaternized and betainized units. Starting with PDMAEMA brushes with constant grafting density and degree of polymerization, we first generate a density gradient of quaternized units by directional vapor reaction involving methyl iodide. The unreacted DMAEMA units are then betainized through gaseous-phase betainization with 1,3-propanesultone. The gas reaction of PDMAEMA with 1,3-propanesultone eliminates the formation of byproducts present during the liquid-phase modification. We use the counterpropagating density gradients of quaternized and betainized PDMAEMA brushes in antibacterial and antifouling studies. Completely quaternized and betainized brushes exhibit antibacterial and antifouling behaviors. Samples containing 12% of quaternized and 85% of betainized units act simultaneously as antibacterial and antifouling surfaces.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Jan Genzer

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